Evidence map›Paper›PMID 34244971›Full record

ReviewStem cell reviews and reports2022

Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression.

Shivani Baisiwala, Shreya Budhiraja, Chirag Goel, Khizar R Nandoliya, Miranda R Saathoff, Atique U Ahmed

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shivani Baisiwala *Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL, 60611, USA.ORCID 0000-0001-5252-9940
Shreya Budhiraja *Northwestern University, Evanston, IL, 60208, USA.
Chirag Goel *Northwestern University, Evanston, IL, 60208, USA.
Khizar R NandoliyaNorthwestern University, Evanston, IL, 60208, USA.
Miranda R SaathoffDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL, 60611, USA.
Atique U AhmedDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, 303 East Superior Street, Chicago, IL, 60611, USA. atique.ahmed@northwestern.edu.

Funding

STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2018 to 2026
$21.4M
Cellular Plasticity and equilibrium in GBM ProgressionR01NS096376 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2017 to 2026
$3.9M
Role of purine metabolism in chemoresistanceR01NS112856 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHMED, ATIQUE U. · 2019 to 2023
$1.7M
NCI NIH HHS P50 CA221747NINDS NIH HHS 1R01NS096376NINDS NIH HHS R01 NS096376NINDS NIH HHS R01 NS112856
6 · The paper itself

Abstract

Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs' contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs' contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics.

Indexed as

NeoplasmsNeoplastic Stem CellsCell Line, TumorHumansCancer stem cellInvasionMetastasisProgressionStem cellTherapeutic resistanceTherapeutics

Identifiers

PMID34244971
PMCPMC9153205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.