Evidence map›Paper›PMID 34244864›Full record

ReviewCurrent neurology and neuroscience reports2021

Civilian Firearm-Inflicted Brain Injury: Coagulopathy, Vascular Injuries, and Triage.

Christos Lazaridis, Ali Mansour, Ronald Alvarado-Dyer, Ruth Tangonan, Andrea Loggini, Christopher Kramer, Fernando D Goldenberg

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Civilian penetrating traumatic brain injury in South-East Norway.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christos LazaridisDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA. lazaridis@uchicago.edu.ORCID http://orcid.org/0000-0003-1814-4830
Ali MansourDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
Ronald Alvarado-DyerDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
Ruth TangonanDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
Andrea LogginiDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
Christopher KramerDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
Fernando D GoldenbergDepartment of Neurology, University of Chicago Medical Center, Chicago, IL, USA.
University of Chicago · USUniversity of Chicago Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewCivilian firearm-inflicted penetrating brain injury (PBI) carries high morbidity and mortality. Concurrently, the evidence base guiding management decisions remains limited. Faced with large volume of PBI patients, we have made observations in relation to coagulopathy and cerebrovascular injuries. We here review this literature in addition to the question about early prognostication as it may inform neurosurgical decision-making. RECENT

findingsThe triad of coagulopathy, low motor score, and radiographic compression of basal cisterns comprises a phenotype of injury with exceedingly high mortality. PBI leads to high rates of cerebral arterial and venous injuries, and projectile trajectory is emerging as an independent predictor of outcome. The combination of coagulopathy with cerebrovascular injury creates a specific endophenotype. The nature and role of coagulopathy remain to be deciphered, and consideration to the use of tranexamic acid should be given. Prospective controlled trials are needed to create clinical evidence free of patient selection bias.

Indexed as

Brain InjuriesHead Injuries, PenetratingVascular System InjuriesHumansProspective StudiesTriageBrain injury coagulopathyFirearm brain injuryNeurosurgical triagePenetrating brain injury

Identifiers

PMID34244864
OpenAlexW3181384268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.