Evidence map›Paper›PMID 34244739›Full record

ArticleThe Journal of infectious diseases2022

Occurrence and Distribution of Nonfalciparum Malaria Parasite Species Among Adolescents and Adults in Malawi.

Austin Gumbo, Hillary M Topazian, Alexis Mwanza, Cedar L Mitchell, Sydney Puerto-Meredith, Ruth Njiko, Michael Kayange, David Mwalilino, Bernard Mvula, Gerald Tegha and 3 more

Open access · greenAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Austin GumboNational Malaria Control Programme, Malawi Ministry of Health, Lilongwe, Malawi.
Hillary M TopazianDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0001-7824-9605
Alexis MwanzaDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Cedar L MitchellDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Sydney Puerto-MeredithDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Ruth NjikoUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
Michael KayangeNational Malaria Control Programme, Malawi Ministry of Health, Lilongwe, Malawi.
David MwalilinoNational HIV Reference Laboratory, Malawi Ministry of Health, Lilongwe, Malawi.
Bernard MvulaNational HIV Reference Laboratory, Malawi Ministry of Health, Lilongwe, Malawi.
Gerald TeghaUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
Tisungane MvaloUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
Irving HoffmanUniversity of North Carolina Project-Malawi, Lilongwe, Malawi.
Jonathan J JulianoDivision of Infectious Diseases, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USPublic Health Institute of Malawi · MWUniversity of Malawi · MW

Funding

Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
NIAID NIH HHS K24 AI134990
6 · The paper itself

Abstract

backgroundPlasmodium falciparum malaria dominates throughout sub-Saharan Africa, but the prevalence of Plasmodium malariae, Plasmodium ovale spp., and Plasmodium vivax increasingly contribute to infection in countries that control malaria using P. falciparum-specific diagnostic and treatment strategies.

methodsWe performed quantitative polymerase chain reaction (qPCR) on 2987 dried blood spots from the 2015-2016 Malawi Demographic and Health Survey to identify presence and distribution of nonfalciparum infection. Bivariate models were used to determine species-specific associations with demographic and environmental risk factors.

resultsNonfalciparum infections had broad spatial distributions. Weighted prevalence was 0.025 (SE, 0.004) for P. malariae, 0.097 (SE, 0.008) for P. ovale spp., and 0.001 (SE, 0.0005) for P. vivax. Most infections (85.6%) had low-density parasitemias ≤ 10 parasites/µL, and 66.7% of P. malariae, 34.6% of P. ovale spp., and 40.0% of P. vivax infections were coinfected with P. falciparum. Risk factors for P. malariae were like those known for P. falciparum; however, there were few risk factors recognized for P. ovale spp. and P. vivax, perhaps due to the potential for relapsing episodes.

conclusionsThe prevalence of any nonfalciparum infection was 11.7%, with infections distributed across Malawi. Continued monitoring of Plasmodium spp. becomes critical as nonfalciparum infections become important sources of ongoing transmission.

Indexed as

AdolescentAdultFemaleHumansMalariaMalaria, VivaxMalawiMalePlasmodium malariaePlasmodium ovalePlasmodium vivaxReal-Time Polymerase Chain ReactionYoung AdultMalariaMalawiP. malariaeP. ovale sppP. vivax

Identifiers

PMID34244739
PMCPMC8763954
OpenAlexW3178233779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.