ArticleHypertension research : official journal of the Japanese Society of Hypertension2021
Nighttime home blood pressure as a mediator of N-terminal pro-brain natriuretic peptide in cardiovascular events.
Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Effects of renal denervation on blood pressures in patients with hypertension: a systematic review and meta-analysis of randomized sham-controlled trials.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Pooled it
- Efficacy of Esaxerenone Plus a Renin-Angiotensin System Inhibitor or Calcium Channel Blocker for Nocturnal Hypertension: A Post Hoc Analysis.American journal of hypertension · 2025Trial
- Associations of Ambulatory Blood Pressure Measurements With High-Sensitivity Troponin and Natriuretic Peptide Levels in SPRINT.American journal of hypertension · 2024Trial
- Acute hot-water immersion augments the diastolic blood pressure nocturnal dip in healthy adults.Experimental physiology · 2026Article
- The prognostic impact of home blood pressure measurements in patients with stage B heart failure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- AI-driven system for non-contact continuous nocturnal blood pressure monitoring using fiber optic ballistocardiography.Communications engineering · 2024Article
- Antihypertensive effect of esaxerenone and correlation between brachial and wrist home monitoring devices in patients with nocturnal hypertension: A post hoc analysis of the EARLY-NH study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Impact of nocturnal blood pressure dipping on recurrence of atrial fibrillation after pulmonary vein isolation.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Development of beat-by-beat blood pressure monitoring device and nocturnal sec-surge detection algorithm.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Article
- Digital hypertension towards to the anticipation medicine.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- What impacts do the new ESH 2023 guidelines have on the management of hypertension in Japan?Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Nighttime home blood pressure lowering effect of esaxerenone in patients with uncontrolled nocturnal hypertension: the EARLY-NH study.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Circadian rhythm in cardiovascular diseases: a bibliometric analysis of the past, present, and future.European journal of medical research · 2023Review
- Ambulatory Blood Pressure Monitoring for Diagnosis and Management of Hypertension in Pregnant Women.Diagnostics (Basel, Switzerland) · 2023Review
- Association of Long-term Change in N-Terminal Pro-B-Type Natriuretic Peptide With Incident Heart Failure and Death.JAMA cardiology · 2023Article
- Update on Hypertension Research in 2021.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Angiotensin receptor-neprilysin inhibitors for hypertension-hemodynamic effects and relevance to hypertensive heart disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Long-term blood pressure lowering effect of renal denervation and its patient preference, salt intake, and stroke in Asia.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Seven-action approaches for the management of hypertension in Asia - The HOPE Asia network.Journal of clinical hypertension (Greenwich, Conn.) · 2022Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We tested our hypothesis that the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiovascular disease (CVD) events is mediated in part by a pathway of increased nighttime blood pressure (BP) that involves volume overload. We used the data from the Japan Morning Surge-Home Blood Pressure (J-HOP) Nocturnal BP Study, which targeted 2476 Japanese participants who had a history of or risk for CVD (mean age 63.8 ± 10.2 years), along with their measured nighttime BP values assessed by a home BP device (measured at 2:00, 3:00 and 4:00 a.m.) and NT-proBNP levels. At baseline, elevated daytime (average of morning and evening) and nighttime home systolic BP (SBP) were independently associated with log-transformed NT-proBNP levels after adjustment for cardiovascular risk factors. During a median follow-up of 7.2 years, 150 participants experienced a CVD event (62 stroke events and 88 coronary artery disease events). After adjustment for cardiovascular risk factors and nighttime SBP, increased log-transformed NT-proBNP levels were independently associated with CVD events (hazard ratio [HR] per 1 unit, 1.67; 95% confidence interval [CI]: 1.16-2.40). Elevated nighttime home SBP was also independently associated with CVD events after adjustment for cardiovascular risk and log-transformed NT-proBNP (HR per standard deviation, 1.22; 95% CI: 1.001-1.50). The percentage of the association between NT-proBNP and CVD events mediated by nighttime home SBP was 15%. Our findings indicate a physiological pathway in which increased nighttime SBP contributes to the impact of elevated NT-proBNP levels on the incidence of CVD.
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