ArticleScientific reports2021
Insights into the molecular properties underlying antibacterial activity of prenylated (iso)flavonoids against MRSA.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Discovery of isokurarinone as an ATCase-engaging lead with potent activity against methicillin-resistantVirulence · 2026Article
- Natural Products and Antimicrobial Nanoparticles Against Methicillin-ResistantPharmaceutics · 2026Review
- Polyphenolic compounds inFrontiers in pharmacology · 2026Review
- Endophytic fungi as a source of antimicrobial compounds against emerging methicillin-resistantMycology · 2026Review
- Effective Membrane Permeabilization of Methicillin-ResistantJournal of natural products · 2025Article
- Unraveling the molecular drivers of antibacterial prenylated (iso)flavonoids and chalcones against Streptococcus mutans.Scientific reports · 2025Article
- Mechanistic Insights into the Membrane Permeabilization Activity of Antimicrobial Prenylated Isoflavonoids: A Comparative Study of Glabridin, Wighteone, and Lupiwighteone.Journal of agricultural and food chemistry · 2025Article
- Molecular features of prenylated (iso)flavonoids from Fabaceae in relation to their potential NorA inhibition inFrontiers in pharmacology · 2025Article
- Therapeutic Potential of Prenylated Flavonoids of the Fabaceae Family in Medicinal Chemistry: An Updated Review.International journal of molecular sciences · 2024Review
- Biotransformation and Epithelial Toxicity of Prenylated Phenolics from Licorice Roots (Journal of agricultural and food chemistry · 2024Article
- Machine Learning-Based Virtual Screening of Antibacterial Agents against Methicillin-Susceptible and ResistantJournal of chemical information and modeling · 2024Article
- Biosynthesis and metabolic engineering of isoflavonoids in model plants and crops: a review.Frontiers in plant science · 2024Review
- Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids.Microbiology spectrum · 2023Article
- Article
- One-Step Synthesis of Self-Stratification Core-Shell Latex for Antimicrobial Coating.Molecules (Basel, Switzerland) · 2023Article
- "Medicine food homology" plants promote periodontal health: antimicrobial, anti-inflammatory, and inhibition of bone resorption.Frontiers in nutrition · 2023Review
- Biofilm Formation and Phospholipase and Proteinase Production inTheScientificWorldJournal · 2023Article
- Review
- Polyphenol and Tannin Nutraceuticals and Their Metabolites: How the Human Gut Microbiota Influences Their Properties.Biomolecules · 2022Review
- Antibacterial Modes of Herbal Flavonoids Combat Resistant Bacteria.Frontiers in pharmacology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High resistance towards traditional antibiotics has urged the development of new, natural therapeutics against methicillin-resistant Staphylococcus aureus (MRSA). Prenylated (iso)flavonoids, present mainly in the Fabaceae, can serve as promising candidates. Herein, the anti-MRSA properties of 23 prenylated (iso)flavonoids were assessed in-vitro. The di-prenylated (iso)flavonoids, glabrol (flavanone) and 6,8-diprenyl genistein (isoflavone), together with the mono-prenylated, 4'-O-methyl glabridin (isoflavan), were the most active anti-MRSA compounds (Minimum Inhibitory Concentrations (MIC) ≤ 10 µg/mL, 30 µM). The in-house activity data was complemented with literature data to yield an extended, curated dataset of 67 molecules for the development of robust in-silico prediction models. A QSAR model having a good fit (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.