Observational studyNature communications2021
A generative network model of neurodevelopmental diversity in structural brain organization.
Observational study in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 74 citations in OpenAlex.
- Heterochronicity shapes brain network formation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Human cortical networks trade communication efficiency for computational reliability.Science advances · 2026Article
- The topology of adolescent mental health.medRxiv : the preprint server for health sciences · 2026Article
- The genetic architecture of cortical similarity networks.Nature communications · 2026Article
- Whole-brain cellular-resolution functional network properties of seizure susceptibility.bioRxiv : the preprint server for biology · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Geometric constraints on the architecture of mammalian cortical connectomes.bioRxiv : the preprint server for biology · 2025Article
- Unifying equivalences across unsupervised learning, network science, and imaging/network neuroscience.ArXiv · 2025Article
- Article
- Premature birth changes wiring constraints in neonatal structural brain networks.Nature communications · 2025Article
- Brain wiring economics, network organisation and population-level genomics.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Coming up short: Generative network models fail to accurately capture long-range connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Metric structural human connectomes: Localization and multifractality of eigenmodes.Network neuroscience (Cambridge, Mass.) · 2025Article
- Shaping dynamical neural computations using spatiotemporal constraints.Biochemical and biophysical research communications · 2024Review
- Contributions of network structure, chemoarchitecture and diagnostic categories to transitions between cognitive topographies.Nature biomedical engineering · 2024Article
- Human adolescent brain similarity development is different for paralimbic versus neocortical zones.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A shifting role of thalamocortical connectivity in the emergence of cortical functional organization.Nature neuroscience · 2024Article
- Screen time, brain network development and socio-emotional competence in childhood: moderation of associations by parent-child reading.Psychological medicine · 2024Article
- Approaches to embryonic neurodevelopment: from neural cell to neural tube formation through mathematical models.Briefings in bioinformatics · 2024Article
- From pixels to connections: exploring in vitro neuron reconstruction software for network graph generation.Communications biology · 2024Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The formation of large-scale brain networks, and their continual refinement, represent crucial developmental processes that can drive individual differences in cognition and which are associated with multiple neurodevelopmental conditions. But how does this organization arise, and what mechanisms drive diversity in organization? We use generative network modeling to provide a computational framework for understanding neurodevelopmental diversity. Within this framework macroscopic brain organization, complete with spatial embedding of its organization, is an emergent property of a generative wiring equation that optimizes its connectivity by renegotiating its biological costs and topological values continuously over time. The rules that govern these iterative wiring properties are controlled by a set of tightly framed parameters, with subtle differences in these parameters steering network growth towards different neurodiverse outcomes. Regional expression of genes associated with the simulations converge on biological processes and cellular components predominantly involved in synaptic signaling, neuronal projection, catabolic intracellular processes and protein transport. Together, this provides a unifying computational framework for conceptualizing the mechanisms and diversity in neurodevelopment, capable of integrating different levels of analysis-from genes to cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.