Evidence map›Paper›PMID 34244442›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor.

Eleni Leventea, Zhou Zhu, Xiaoming Fang, Yulia Nikolaeva, Eleanor Markham, Robert A Hirst, Fredericus J M van Eeden, Jarema J Malicki

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Knockout ofBiomedicines · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Advances in otolith-related protein research.Frontiers in neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Eleni LeventeaDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Zhou ZhuDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Xiaoming FangDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0001-8102-7501
Yulia NikolaevaDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.
Eleanor MarkhamDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID 0000-0002-4134-1042
Robert A HirstDepartment of Respiratory Sciences, University of Leicester, Leicester LE1 7RH, United Kingdom.ORCID 0000-0003-1989-1790
Fredericus J M van EedenDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom; f.j.vaneeden@sheffield.ac.uk.
Jarema J MalickiDepartment of Biomedical Science, University of Sheffield, Sheffield S10 2TN, United Kingdom.
University of Sheffield · GBUniversity of Leicester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/R005192/1Biotechnology and Biological Sciences Research Council BB/R015457/1Medical Research Council MR/N000714/1
6 · The paper itself

Abstract

Here, we report that important regulators of cilia formation and ciliary compartment-directed protein transport function in secretion polarity. Mutations in cilia genes

Indexed as

Amino Acid SequenceAnimalsBardet-Biedl SyndromeBase SequenceCiliaCiliopathiesCrystallizationEpistasis, GeneticExtracellular Matrix ProteinsGene Expression Regulation, DevelopmentalHomozygoteMutationOtolithic MembranePhenotypeZebrafishZebrafish Proteinscoch protein, zebrafishExtracellular Matrix ProteinsZebrafish Proteinsapical secretioncep290Cochlinearotolith

Identifiers

PMID34244442
PMCPMC8285972
OpenAlexW3181239616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.