Evidence map›Paper›PMID 34244433›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Identification of simple arylfluorosulfates as potent agents against resistant bacteria.

Jiong Zhang, Xiangxiang Zhao, John R Cappiello, Yi Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu Luo, Yu Zhang, Jiajia Dong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Diversity Oriented Clicking for Modular Synthesis.Nature reviews. Methods primers · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Sulfur fluoride exchange.Nature reviews. Methods primers · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jiong ZhangKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, 200032 Shanghai, China.ORCID 0000-0003-3578-416X
Xiangxiang ZhaoState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237 Shanghai, China.ORCID 0000-0001-7758-4428
John R CappielloDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Yi YangDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Yunfei ChengDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.
Guang LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237 Shanghai, China.ORCID 0000-0003-0468-1061
Wenjing FangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237 Shanghai, China.ORCID 0000-0002-3805-1482
Yinzhu LuoGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 510663 Guangzhou, China.
Yu ZhangGuangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 510663 Guangzhou, China.
Jiajia DongKey Laboratory of Organofluorine Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, 200032 Shanghai, China; jiajia@sioc.ac.cn lxzhang@ecust.edu.cn sharples@scripps.edu.
Lixin ZhangState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 200237 Shanghai, China; jiajia@sioc.ac.cn lxzhang@ecust.edu.cn sharples@scripps.edu.ORCID 0000-0003-0894-9520
K Barry SharplessDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; jiajia@sioc.ac.cn lxzhang@ecust.edu.cn sharples@scripps.edu.

Funding

Sulfur(VI) Fluoride Exchange (SuFEx): new developments and biological applicationsR01GM117145 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SHARPLESS, KARL BARRY · 2016 to 2023
$3.9M
NIGMS NIH HHS R01 GM117145
6 · The paper itself

Abstract

Sulfur fluoride exchange (SuFEx), a next generation of click chemistry, opens an avenue for drug discovery. We report here the discovery and structure-activity relationship studies of a series of arylfluorosulfates, synthesized via SuFEx, as antibacterial agents. Arylfluorosulfates 3, 81, and 101 showed potency to overcome multidrug resistance and were not susceptible to the generation of resistance. They exhibited rapid bactericidal potency and selectively killed gram-positive bacterial strains. These compounds also exhibited the ability to disrupt established bacterial biofilm and kill persisters derived from biofilm. Furthermore, arylfluorosulfate 3 had a synergistic effect with streptomycin and gentamicin. In addition, their anti-MRSA potency was evaluated and determined by the

Indexed as

Drug Resistance, BacterialAnimalsAnti-Bacterial AgentsBiofilmsCaenorhabditis elegansDisease Models, AnimalHEK293 CellsHumansKineticsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsPhenotypeStructure-Activity RelationshipSulfatesAnti-Bacterial AgentsSulfatesantibacterial agentsbiofilm disruptionclick chemistrymultidrug resistanceSuFEx

Identifiers

PMID34244433
PMCPMC8285976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.