Evidence map›Paper›PMID 34244347›Full record

ArticleGut2022

Hidden link in gut-joint axis: gut microbes promote rheumatoid arthritis at early stage by enhancing ascorbate degradation.

Yan Zhao, Mingyue Cheng, Liang Zou, Luxu Yin, Chaofang Zhong, Yuguo Zha, Xue Zhu, Lei Zhang, Kang Ning, Jinxiang Han

Abstract readLetterComment
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Microbial threads in the tapestry of rheumatoid arthritis.The Journal of clinical investigation · 2025
    Review
  6. Review
  7. Biomolecules · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. GutFrontiers in immunology · 2024
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yan Zhao *First Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID 0000-0002-2816-8951
Mingyue Cheng *Key Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0003-1243-5039
Liang ZouFirst Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID 0000-0003-0899-2318
Luxu YinFirst Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.ORCID 0000-0003-2374-9965
Chaofang ZhongKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Yuguo ZhaKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0003-3702-9416
Xue ZhuKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.ORCID 0000-0002-7337-6186
Lei ZhangMicrobiome-X, National Institute of Health Data Science of China & Institute for Medical Dataology, Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China zhanglei7@sdu.edu.cn ningkang@hust.edu.cn jxhan@sdfmu.edu.cn.ORCID 0000-0003-4284-2604
Kang NingKey Laboratory of Molecular Biophysics of the Ministry of Education, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Center for Artificial Intelligence Biology, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China zhanglei7@sdu.edu.cn ningkang@hust.edu.cn jxhan@sdfmu.edu.cn.ORCID 0000-0003-3325-5387
Jinxiang HanFirst Affiliated Hospital of Shandong First Medical University, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China zhanglei7@sdu.edu.cn ningkang@hust.edu.cn jxhan@sdfmu.edu.cn.ORCID 0000-0001-9269-4553

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Arthritis, RheumatoidGastrointestinal MicrobiomeDysbiosisHumansarthritisgut inflammationintestinal bacteriavitamins

Identifiers

PMID34244347
PMCPMC8995803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.