Evidence map›Paper›PMID 34244262›Full record

ArticleBMJ open2021

Interventional treatments for chronic, axial or radicular, non-cancer, spinal pain: a protocol for a systematic review and network meta-analysis of randomised trials.

Xiaoqin Wang, Grace Martin, Behnam Sadeghirad, Andrea J Darzi, Rachel J Couban, Ivan D Florez, Holly N Crandon, Elena Kum, Yaping Chang, Meisam Abdar Esfahani and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xiaoqin WangMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Grace MartinMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Behnam SadeghiradMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9422-5232
Andrea J DarziDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Rachel J CoubanMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Ivan D FlorezDepartment of Pediatrics, Universidad de Antioquia, Medellin, Colombia.ORCID 0000-0002-0751-8932
Holly N CrandonFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Elena KumDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Yaping ChangDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Meisam Abdar EsfahaniDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Laxsanaa SivananthanGraduate Entry Medical School, University of Limerick, Limerick, Ireland.
Fatemeh MehrabiPharmaceutic Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.
Neil K SenguptaMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Preksha RathodMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Rami Z MorsiDepartment of Neurology, University of Chicago, Chicago, Illinois, USA.
D Norman BuckleyMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada.
Gordon H GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Y Raja RampersaudArthritis Program, Krembil Research Institute, Division of Orthopaedics, University Health Network, Toronto, Ontario, Canada.
Christopher J StandaertDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Thomas AgoritsasDivision General Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Jason W BusseMichael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Ontario, Canada bussejw@mcmaster.ca.ORCID 0000-0002-0178-8712

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic, non-cancer, axial or radicular spinal pain is a common condition associated with considerable socioeconomic burden. Clinicians frequently offer patients various interventional procedures for the treatment of chronic spine pain; however, the comparative effectiveness and safety of available procedures remains uncertain.

methodsWe will conduct a systematic review of randomised controlled trials that explores the effectiveness and harms of interventional procedures for the management of axial or radicular, chronic, non-cancer, spine pain. We will identify eligible studies through a systematic search of Medline, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials and Web of Science from inception without language restrictions. Eligible trials will: (1) enrol primarily adult patients (≥18 years old) with axial or radicular, chronic, non-cancer, spine pain, (2) randomise patients to different, currently available, interventional procedures or to an interventional procedure and a placebo/sham procedure or usual care, and (3) measure outcomes at least 1 month after randomisation.Pairs of reviewers will independently screen articles identified through searches and extract information and assess risk of bias of eligible trials. We will use a modified Cochrane instrument to evaluate risk of bias. We will use frequentist random-effects network meta-analyses to assess the relative effects of interventional procedures, and five a priori hypotheses to explore between studies subgroup effects. We will use the Grading of Recommendations Assessment, Development and Evaluation approach to assess the certainty in evidence for each outcome, including direct, indirect and network estimates. ETHICS AND DISSEMINATION: No research ethics approval is required for this systematic review, as no confidential patient data will be used. We will disseminate our findings through publication in a peer-reviewed journal and conference presentations, and our review will support development of a PROSPERO REGISTRATION NUMBER: CRD42020170667.

Indexed as

Chronic PainMusculoskeletal PainAdolescentAdultHumansNetwork Meta-Analysis as TopicRandomized Controlled Trials as TopicSystematic Reviews as Topicback paininterventional radiologypain managementrehabilitation medicinespine

Identifiers

PMID34244262
PMCPMC8273478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.