Observational studyJournal of orthopaedic surgery and research2021
The incidence and risk factors of deep venous thrombosis in lower extremities following surgically treated femoral shaft fracture: a retrospective case-control study.
Observational study in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Pooled it
- Risk factors for venous thromboembolism following surgical treatment of fractures: A systematic review and meta-analysis.International wound journal · 2023Pooled it
- Efficacy of Atorvastatin Against Venous Thromboembolism After Total Hip Arthroplasty.Journal of musculoskeletal & neuronal interactions · 2025Trial
- Aspirin for Venous Thromboembolism Prevention in Orthopaedic Surgery with Focus on Trauma and Arthroplasty: A Structured Evidence-Based Review of Randomised Trials, Guidelines, and Contemporary Practice Considerations.Journal of clinical medicine · 2026Review
- Platelet count, fibrinogen and ROTEM® parameters predict deep vein thrombosis in elderly patients with femoral fracture.Journal of anesthesia, analgesia and critical care · 2026Article
- Development of a predictive nomogram for perioperative lower extremity deep vein thrombosis in patients with breast cancer and the efficacy of dextran 40 prophylaxis.American journal of cancer research · 2026Article
- Pulmonary Embolism Despite Inferior Vena Cava Filter in a Polytrauma Patient: A Case Report.Case reports in orthopedics · 2026Article
- Rapid-Onset Venous Thrombosis After Tibia Fracture: A Case Report.The American journal of case reports · 2025Article
- Analysis of risk factors and construction of prediction model for lower extremity deep vein thrombosis after liver transplantation.European journal of medical research · 2025Article
- Platelet-to-lymphocyte ratio as a predictor of preoperative venous thrombosis in femoral fracture patients: a retrospective cohort study.Frontiers in cardiovascular medicine · 2025Article
- Time, Tumor, and Thrombosis: Drivers of 30-Day VTE After Femoral Fracture Surgery.Orthopedic reviews · 2025Article
- Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty.BMC surgery · 2024Article
- Distribution characteristics of perioperative deep vein thrombosis (DVT) and risk factors of postoperative DVT exacerbation in patients with thoracolumbar fractures caused by high-energy injuries.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- A nomogram to predict postoperative deep vein thrombosis in patients with femoral fracture: a retrospective study.Journal of orthopaedic surgery and research · 2023Article
- Incidence and Related Factors for Low-Extremity Deep Vein Thrombosis in Breast Cancer Patients Who Underwent Surgical Resection: What Do We Know and What Should We Care.Frontiers in surgery · 2022Article
- Dynamic Changes and Relevant Factors of Perioperative Deep Vein Thrombosis in Patients with Thoracolumbar Fractures Caused by High-Energy Injuries.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is still a lack of data on deep vein thrombosis (DVT) following surgically treated femoral shaft fracture (FSF). The goal of this study was to investigate the characteristics of postoperative DVT and the association between the occurrence of DVT and risk factors in patients undergoing surgical treatment for FSF.
methodsThis observational retrospective case-control study reviewed 308 patients who received surgical treatment of FSF between January 2016 and October 2020 at a university hospital. Univariate analyses were performed on the data of demographics, comorbidities, laboratory biomarkers, and operation-related indexes. The receiver operating characteristic (ROC) curve analysis, univariate analyses, and multivariate logistic regression analysis were employed to identify the independent risk factors associated with DVT.
resultsIn total, 308 patients with surgically treated FSF were included, among whom 48 (15.6%) patients had postoperative DVTs. The univariate analyses showing significant differences regarding DVT were American Society of Anesthesiologists (ASA) classification, diabetes mellitus, current smoking, aspartate transaminase (AST), and very-low-density lipoprotein (VLDL) level among the 34 factors. According to the ROC results, the optimal cutoff values for intraoperative blood loss, D-dimer, and age were 350 ml, 1.08 μg/ml, and 35 years, respectively. The multivariable model demonstrated 4 significantly independent associations with postoperative DVT, including current smoking, intraoperative blood loss (> 550 ml), age (> 35 years), and D-dimer > 1.09 μg/ml.
conclusionThese risk factors as screening tools contribute to risk stratification of the occurrence of thromboembolic events. In addition, our findings would help orthopedic surgeons make a cross-specialty decision and implement targeted precaution measures for patients with FSF.
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