Evidence map›Paper›PMID 34243756›Full record

SynthesisJournal of the International Society of Sports Nutrition2021

The effects of dietary nitrate supplementation on endurance exercise performance and cardiorespiratory measures in healthy adults: a systematic review and meta-analysis.

Chloe Gao, Saurabh Gupta, Taranah Adli, Winston Hou, Reid Coolsaet, Abigail Hayes, Kevin Kim, Arjun Pandey, Jacob Gordon, Gurneet Chahil and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the International Society of Sports Nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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  7. Effectiveness of Nitrate Intake on Recovery from Exercise-Related Fatigue: A Systematic Review.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Chloe GaoFaculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Saurabh GuptaDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada.
Taranah AdliFaculty of Biomedical Sciences, University of Western Ontario, London, Ontario, Canada.
Winston HouFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Reid CoolsaetUniversity of Guelph, Guelph, Ontario, Canada.
Abigail HayesQueen's University, Kingston, Ontario, Canada.
Kevin KimMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.
Arjun PandeyFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Jacob GordonFaculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Gurneet ChahilPopulation Health Research Institute, Hamilton, Ontario, Canada.
Emilie P Belley-CotePopulation Health Research Institute, Hamilton, Ontario, Canada.
Richard P WhitlockDepartment of Surgery, McMaster University, Hamilton, Ontario, Canada. richard.whitlock@phri.ca.ORCID http://orcid.org/0000-0002-6863-5884
McMaster University Medical Centre · CAPopulation Health Research Institute · CAQueen's University · CAUniversity of British Columbia · CAUniversity of Guelph · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNitrate supplementation is thought to improve performance in endurance sports.

objectiveTo meta-analyze studies evaluating the effect of nitrate supplementation on endurance sports performance among adults. DATA SOURCES: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, Web of Science and CINAHL without language restrictions.

methodsWe included studies that: 1) compared nitrate supplementation with placebo; 2) enrolled adults engaging in an endurance-based activity; and 3) reported a performance measure or surrogate physiologic outcome. We evaluated risk of bias using the Cochrane Collaboration tool and pooled data with a random-effects model. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to evaluate confidence in estimates.

resultsWe included 73 studies (n = 1061). Nitrate supplementation improved power output (MD 4.6 watts, P < 0.0001), time to exhaustion (MD 25.3 s, P < 0.00001), and distance travelled (MD 163.7 m, P = 0.03). We found no significant difference on perceived exertion, time trial performance and work done. Nitrate supplementation decreased VO

conclusionThe available evidence suggests that dietary nitrate supplementation benefits performance-related outcomes for endurance sports.

Indexed as

Dietary SupplementsAdultAthletesAthletic PerformanceBiasCardiorespiratory FitnessExercise ToleranceHumansLactic AcidNitratesOxygen ConsumptionPhysical EndurancePublication BiasSedentary BehaviorTime FactorsLactic AcidNitratesEndurance exerciseNitrate supplementationSystematic review and meta-analysis

Identifiers

PMID34243756
PMCPMC8268374
OpenAlexW3181601537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.