Evidence map›Paper›PMID 34243315›Full record

ArticleThe Review of scientific instruments2021

High-power near-concentric Fabry-Perot cavity for phase contrast electron microscopy.

Carter Turnbaugh, Jeremy J Axelrod, Sara L Campbell, Jeske Y Dioquino, Petar N Petrov, Jonathan Remis, Osip Schwartz, Zanlin Yu, Yifan Cheng, Robert M Glaeser and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Review of scientific instruments, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  11. CryomicroscopyFaraday discussions · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Conquer by cryo-EM without physically dividing.Biochemical Society transactions · 2021
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Carter TurnbaughDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.ORCID 0000000251328087
Jeremy J AxelrodDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.ORCID 000000033564241X
Sara L CampbellDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.ORCID 0000000273358391
Jeske Y DioquinoDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.
Petar N PetrovDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.ORCID 000000023806534X
Jonathan RemisCalifornia Institute for Quantitative Biosciences (QB3), University of California, Berkeley, California 94720, USA.
Osip SchwartzDepartment of Physics of Complex Systems, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000000319551825
Zanlin YuDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, USA.
Yifan ChengDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94158, USA.ORCID 0000000183818788
Robert M GlaeserLawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA.
Holger MuellerDepartment of Physics, 366 Physics MS 7300, University of California-Berkeley, Berkeley, California 94720, USA.
Lawrence Berkeley National Laboratory · USHoward Hughes Medical Institute · USQB3 · USUniversity of California, Berkeley · USUniversity of California, San Francisco · USWeizmann Institute of Science · IL

Funding

Development of Laser-Based Phase Contrast for Biological Electron MicroscopyR01GM126011 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI MUELLER, HOLGER · 2017 to 2024
$3.9M
NIGMS NIH HHS R01 GM126011
6 · The paper itself

Abstract

Transmission electron microscopy (TEM) of vitrified biological macromolecules (cryo-EM) is limited by the weak phase contrast signal that is available from such samples. Using a phase plate would thus substantially improve the signal-to-noise ratio. We have previously demonstrated the use of a high-power Fabry-Perot cavity as a phase plate for TEM. We now report improvements to our laser cavity that allow us to achieve record continuous wave intensities of over 450 GW/cm

Identifiers

PMID34243315
PMCPMC8159438
OpenAlexW3113307050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.