ArticleMolecular immunology2021
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement.
Article in Molecular immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Autoimmune diseases in the era of COVID-19: emerging mechanisms, clinical implications, vaccine considerations, and future directions.The Korean journal of internal medicine · 2026Review
- Pediatric autoimmune diseases in the light of COVID-19 pandemic, A retrospective observational big data study.Journal of translational autoimmunity · 2025Article
- Identification of Putative Serum Autoantibodies Associated with Post-Acute Sequelae of COVID-19 via Comprehensive Protein Array Analysis.International journal of molecular sciences · 2025Article
- The Onset of Antinuclear Antibodies (ANAs) as a Potential Risk Factor for Mortality and Morbidity in COVID-19 Patients: A Single-Center Retrospective Study.Biomedicines · 2024Article
- New-onset autoimmune disease after COVID-19.Frontiers in immunology · 2024Article
- Pulmonary alveolar proteinosis following severe COVID - 19 infection: A case report.Respiratory medicine case reports · 2024Article
- The correlation between corona virus disease 2019 and alopecia areata: a literature review.Frontiers in immunology · 2024Review
- Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses.Nature communications · 2023Article
- Molecular Mimicry between SARS-CoV-2 Proteins and Human Self-Antigens Related with Autoimmune Central Nervous System (CNS) Disorders.Microorganisms · 2023Article
- Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19.JAMA network open · 2023Article
- SARS-CoV-2 Gut-Targeted Epitopes: Sequence Similarity and Cross-Reactivity Join Together for Molecular Mimicry.Biomedicines · 2023Article
- Case report: Unusual patient with dermatomyositis associated with SARS-CoV-2 infection.Frontiers in neurology · 2023Article
- Anti-cardiolipin IgG autoantibodies associate with circulating extracellular DNA in severe COVID-19.Scientific reports · 2022Article
- [Antiphospholipid autoantibodies and Covid-19].Revue francophone des laboratoires : RFL · 2022Article
- Polymyositis: The Comet Tail After COVID-19.Cureus · 2022Article
- Article
- Review
- COVID-19 and fertility-at the crossroads of autoimmunity and thrombosis.Rheumatology international · 2021Review
- Pulmonary-renal Syndrome Caused by an Overlap Systemic Lupus Erythematosus/Antineutrophil Cytoplasmic Antibody-associated Vasculitis Syndrome in the Setting of Immune Complex-mediated Glomerulonephritis in a Patient with COVID-19 Infection.Journal of global infectious diseasesArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity is gaining attention and, in the present study, we have identified 28 human proteins harbouring regions homologous to SARS-CoV-2 peptides that could possibly be acting as autoantigens in COVID-19 patients displaying autoimmune conditions. Interestingly, these conserved regions are amongst the experimentally validated B cell epitopes of SARS-CoV-2 proteins. The reported human proteins have demonstrated presence of autoantibodies against them in typical autoimmune conditions which may explain the frequent occurrence of autoimmune conditions following SARS-CoV-2 infection. Moreover, the proposed autoantigens' widespread tissue distribution is suggestive of their involvement in multi-organ manifestations via molecular mimicry. We opine that our report may aid in directing subsequent necessary antigen-specific studies, results of which would be of long-term relevance in management of extrapulmonary symptoms of COVID-19.
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