Evidence map›Paper›PMID 34242830›Full record

ArticleWorld neurosurgery2021

Aneurysmal Subarachnoid Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series.

William S Dodd, Pascal M Jabbour, Ahmad Sweid, Stavropoula Tjoumakaris, Michael R Gooch, Fadi Al Saiegh, David M Hasan, Robert M Starke, Peter T Kan, Adam J Polifka and 5 more

Abstract read
In one paragraph

Article in World neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Characteristics of subarachnoid hemorrhage associated with COVID-19 infection: A systematic review and descriptive analysis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

William S DoddDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Pascal M JabbourDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ahmad SweidDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Stavropoula TjoumakarisDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Michael R GoochDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Fadi Al SaieghDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
David M HasanDepartment of Neurosurgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
Robert M StarkeDepartment of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Peter T KanDepartment of Neurosurgery, University of Texas Medical Branch, Galveston, Texas, USA.
Adam J PolifkaDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Dimitri LaurentDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Katharina M BuslDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA; Department of Neurology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Ritam GhoshDepartment of Neurological Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Brian L HohDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA.
Nohra ChalouhiDepartment of Neurosurgery, College of Medicine, University of Florida, Gainesville, Florida, USA. Electronic address: nohra.elchalouhi@neurosurgery.ufl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is a pressing public health issue. Although most cases do not result in severe illness requiring hospitalization, there is increasing evidence that SARS-CoV-2-induced inflammation can exacerbate pre-existing diseases. We sought to describe the characteristics of patients with aneurysmal subarachnoid hemorrhage who were actively or very recently infected with SARS-CoV-2.

methodsWe reviewed subarachnoid hemorrhage cases of patients who also were positive for SARS-CoV-2 at 5 high-volume cerebrovascular centers in the United States from March 2020 to January 2021. Cases of aneurysmal subarachnoid hemorrhage were analyzed.

resultsA total of 10 patients were identified, consisting of 5 women (50%) and 5 men (50%). Median age was 38.5 years. Four of the 10 patients (40%) were asymptomatic with respect to SARS-CoV-2-related symptoms, 3 patients (30%) had mild-to-moderate symptoms, and 3 patients (30%) had severe coronavirus disease 2019 (COVID-19), with pneumonia and sepsis. Of the 10 cases, 4 had dissecting pseudoaneurysms (40%), 3 in the posterior circulation and 1 in the anterior circulation. Among 6 saccular/blister aneurysms, 4 (67%) were ≤4 mm in largest diameter.

conclusionsOur experience with aneurysmal subarachnoid hemorrhage in patients positive for COVID-19 reveals a possibly distinct pattern compared with traditional aneurysmal subarachnoid hemorrhage, namely a high frequency of small aneurysms, dissecting pseudoaneurysms, and young patients.

Indexed as

AdultAge FactorsCOVID-19FemaleHospitalizationHumansIntracranial AneurysmMaleMiddle AgedRetrospective StudiesSubarachnoid HemorrhageYoung AdultCerebral aneurysmCOVID-19SARS-CoV-2StrokeSubarachnoid hemorrhage

Identifiers

PMID34242830
PMCPMC8260497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.