Evidence map›Paper›PMID 34242819›Full record

ArticleCellular and molecular gastroenterology and hepatology2021

PIR-B Regulates CD4

Jazib Uddin, Sunil Tomar, Ankit Sharma, Lisa Waggoner, Varsha Ganesan, Sahiti Marella, Yanfen Yang, Taeko Noah, Simone Vanoni, Andrew Patterson and 12 more

Open access · goldAbstract read
In one paragraph

Article in Cellular and molecular gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 4 countries.

Jazib UddinDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan; Graduate Program in Immunology, Ann Arbor, Michigan.
Sunil TomarDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan.
Ankit SharmaDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan.
Lisa WaggonerDivision of Allergy and Immunology, Cincinnati, Ohio.
Varsha GanesanDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan.
Sahiti MarellaDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan.
Yanfen YangDivision of Allergy and Immunology, Cincinnati, Ohio.
Taeko NoahDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan.
Simone VanoniDivision of Allergy and Immunology, Cincinnati, Ohio.
Andrew PattersonDivision of Immunobiology, Cincinnati, Ohio.
Chang ZengDivision of Allergy and Immunology, Cincinnati, Ohio.
Paul S FosterSchool of Biomedical Sciences and Pharmacy, University of Newcastle and Hunter Medical Research Institute, Newcastle, Australia.
Rodney NewberryDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.
Shrinivas BishuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ann Arbor, Michigan.
John Y KaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Ann Arbor, Michigan.
Michael J RosenDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati, Ohio.
Lee DensonDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Cincinnati, Ohio.
Philip D KingDepartment of Microbiology and Immunology, Ann Arbor, Michigan.
Kasper HoebeDivision of Immunobiology, Cincinnati, Ohio; Janssen, Inc, Janssen R@D, Discovery, Innate Immunology Spring House, Pennsylvania.
Senad DivanovicDivision of Immunobiology, Cincinnati, Ohio; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Ariel MunitzDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Simon P HoganDivision of Experimental Pathology, Department of Pathology, Ann Arbor, Michigan; Mary H Weiser Food Allergy Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan. Electronic address: sihogan@med.umich.edu.
Michigan Medicine · USCincinnati Children's Hospital Medical Center · USHunter Medical Research Institute · AUJanssen (Belgium) · BETel Aviv University · ILUniversity of Cincinnati · USWashington University in St. Louis · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
Immunopathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK099222 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic · 2013 to 2026
$5.6M
Type 2 cytokines and innate lymphoid cells in pediatric ulcerative colitisR01DK117119 · NIDDK · STANFORD UNIVERSITY · PI ROSEN, MICHAEL J · 2018 to 2022
$2.5M
Food Allergy and Goblet Cell Antigen PassagesR01AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK, NEWBERRY, RODNEY D · 2015 to 2019
$2.4M
Pro-Type 2 Goblet Cell Antigen Passages in Food Sensitization and ReactivityR37AI112626 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMON Patrick HOGAN, Rodney D Newberry · 2023 to 2026
$2.2M
Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric CorticoR01DK090119 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI HOGAN, SIMON PATRICK · 2012 to 2015
$1.3M
Intestinal epithelial immunological responses and food allergen samplingR21AI138177 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOGAN, SIMON PATRICK · 2019 to 2020
$429k
The Regulatory Role of PIRB in CD4+ Th17 Mediated ColitisF31DK125007 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI UDDIN, JAZIB NASEER · 2020 to 2021
$76k
NIAID NIH HHS R01 AI112626NIAID NIH HHS R21 AI138177NIAID NIH HHS R37 AI112626NIAID NIH HHS T32 AI007413NIDDK NIH HHS F31 DK125007NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK090119NIDDK NIH HHS R01 DK099222NIDDK NIH HHS R01 DK117119
6 · The paper itself

Abstract

BACKGROUND &

aimsCD4

methodsWe used Il10

resultsWe identified PIR-B expression on memory CD4

conclusionsOur findings show an intrinsic role for PIR-B/LILRB3 in the regulation of CD4

Indexed as

Gene Expression RegulationImmunomodulationAnimalsBiomarkersCell SurvivalColitisDisease Models, AnimalDisease SusceptibilityGene Expression ProfilingImmunohistochemistryImmunologic MemoryImmunophenotypingInflammatory Bowel DiseasesInterleukin-10Interleukin-17Intestinal MucosaBiomarkersInterleukin-10Interleukin-17Pirb protein, mouseReceptors, ImmunologicCD4(+) T CellsInflammatory Bowel DiseaseInterleukin 17Paired Immunoglobulin Receptor

Identifiers

PMID34242819
PMCPMC8531983
OpenAlexW3181402447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.