Evidence map›Paper›PMID 34242494›Full record

ArticleCPT: pharmacometrics & systems pharmacology2021

V

Jos Lommerse, Nele Plock, S Y Amy Cheung, Jeffrey R Sachs

Abstract read
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. VCPT: pharmacometrics & systems pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jos LommerseCertara Strategic Consulting, Princeton, NJ, USA.
Nele PlockCertara Strategic Consulting, Princeton, NJ, USA.
S Y Amy CheungCertara Strategic Consulting, Princeton, NJ, USA.
Jeffrey R SachsPharmacokinetics, Pharmacodynamics, and Drug Metabolism-Quantitative Pharmacology and Pharmacometrics, Research Laboratories of Merck & Co., Inc., Kenilworth, NJ, USA.ORCID 0000-0001-5725-558X

Funding

Certara, Inc.Merck Sharp & Dohme Corp.
6 · The paper itself

Abstract

Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with multiple covariates is needed because sparsity of data in visualizations trellised by covariate values can raise concerns about the credibility of the underlying model. V

Indexed as

Clinical Decision-MakingComputer SimulationModels, BiologicalDrug DevelopmentHumansPharmacokinetics

Identifiers

PMID34242494
PMCPMC8452296

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.