Evidence map›Paper›PMID 34242477›Full record

ArticleJournal of thrombosis and haemostasis : JTH2021

Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study.

Jana J Anderson, Frederick K Ho, Claire L Niedzwiedz, Srinivasa Vittal Katikireddi, Carlos Celis-Morales, Stamatina Iliodromiti, Paul Welsh, Pierpaolo Pellicori, Evangelia Demou, Claire E Hastie and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Jana J AndersonInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0001-7290-6635
Frederick K HoInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Claire L NiedzwiedzInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Srinivasa Vittal KatikireddiMRC/CSO Social and Public Health Sciences Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Carlos Celis-MoralesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Stamatina IliodromitiCentre of Women's Health, Yvonne Carter Building, Queen Mary University of London, London, UK.
Paul WelshInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Pierpaolo PellicoriRobertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Evangelia DemouMRC/CSO Social and Public Health Sciences Unit, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.ORCID 0000-0001-8616-525X
Claire E HastieInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Donald M LyallInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Stuart R GrayInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
John F ForbesSchool of Medicine, University of Limerick, Limerick, Ireland.
Jason M R GillInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Daniel F MackayInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Colin BerryInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
John G F ClelandRobertson Centre for Biostatistics, Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.
Jill P PellInstitute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
University of Glasgow · GBMRC/CSO Social and Public Health Sciences Unit · GBQueen Mary University of London · GBUniversity of Limerick · IE

Funding

British Heart Foundation RE/18/6134217Chief Scientist Office SCAF/15/02Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00022/2Medical Research Council MC_UU_12017/13Medical Research Council MR/N003403/1Medical Research Council MR/R024774/1
6 · The paper itself

Abstract

backgroundVenous thromboembolism (VTE) is a common, life-threatening complication of COVID-19 infection. COVID-19 risk-prediction models include a history of VTE. However, it is unclear whether remote history (>9 years previously) of VTE also confers increased risk of COVID-19.

objectivesTo investigate possible association between VTE and COVID-19 severity, independent of other risk factors.

methodsCohort study of UK Biobank participants recruited between 2006 and 2010. Baseline data, including history of VTE, were linked to COVID-19 test results, COVID-19-related hospital admissions, and COVID-19 deaths. The risk of COVID-19 hospitalization or death was compared for participants with a remote history VTE versus without. Poisson regression models were run univariately then adjusted stepwise for sociodemographic, lifestyle, and comorbid covariates.

resultsAfter adjustment for sociodemographic and lifestyle confounders and comorbid conditions, remote history of VTE was associated with nonfatal community (RR 1.61, 95% CI 1.02-2.54, p = .039), nonfatal hospitalized (RR 1.52, 95% CI 1.06-2.17, p = .024) and severe (hospitalized or fatal) (RR 1.40, 95% CI 1.04-1.89, p = .025) COVID-19. Associations with remote history of VTE were stronger among men (severe COVID-19: RR 1.68, 95% CI 1.14-2.42, p = .009) than for women (severe COVID-19: RR 1.07, 95% CI 0.66-1.74, p = .786).

conclusionOur findings support inclusion of remote history of VTE in COVID-19 risk-prediction scores, and consideration of sex-specific risk scores.

Indexed as

COVID-19Venous ThromboembolismVenous ThrombosisAgedBiological Specimen BanksCohort StudiesFemaleHumansMaleRisk FactorsSARS-CoV-2United KingdomCOVID-19 severityDVTPESARS-CoV2 infectionvenous thromboembolism

Identifiers

PMID34242477
PMCPMC8420476
OpenAlexW3181025849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.