ArticlePloS one2021
Micro-computed tomography with contrast enhancement: An excellent technique for soft tissue examination in humans.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Beyond the surface: A review of current and potential micro-CT applications in paleopathology.International journal of paleopathology · 2026Review
- Anatomical layer analysis for safe thread insertion using micro-CT and ultrasonography: enhancing precision in facial thread-lifting procedures.Frontiers in medicine · 2026Article
- Filler Injection Techniques and Ultrasound Observations: Ultrasound-Based Classification of Volume Deficiency in Nasolabial Folds.Aesthetic plastic surgery · 2026Article
- High-Resolution 3-Dimensional Micro-CT Imaging of Intervertebral Discs Using a Novel Contrast Agent.JOR spine · 2025Article
- Effects of chloroquine and hydroxychloroquine on bone health (Review).Molecular medicine reports · 2025Review
- The use of ethanol as contrast enhancer in synchrotron X-ray phase-contrast imaging leads to heterogeneous myocardial tissue shrinkage: a case report.Journal of synchrotron radiation · 2025Article
- Phosphotungstic acid-enhanced micro-computed tomography and RNA sequencing provide a new perspective on temporomandibular joint arthritis induced by complete Freund's adjuvant and collagen-induced arthritis in rat models.Journal of dental sciences · 2025Article
- Micro-CT study of human laryngeal structures using phosphotungstic agent staining.Surgical and radiologic anatomy : SRA · 2024Article
- Advanced soft tissue visualization in conjunction with bone structures using contrast-enhanced micro-CT.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Vascular Perspectives of the Midfacial Superficial Musculoaponeurotic System.Diagnostics (Basel, Switzerland) · 2024Article
- 3D atlas of the human fetal chondrocranium in the middle trimester.Scientific data · 2024Article
- Observation of Anatomical Structures in the Human Larynx Using Micro-Computed Tomography with Lugol's Solution Enhancement.Diagnostics (Basel, Switzerland) · 2023Article
- Lifting the Anterior Midcheek and Nasolabial Fold: Introduction to the Melo Fat Pad Anatomy and Its Role in Longevity and Recurrence.Aesthetic surgery journal · 2023Article
- The Surgical Anatomy of the Jowl and the Mandibular Ligament Reassessed.Aesthetic plastic surgery · 2023Article
- Enhanced study of facial soft tissues using a novel large scale histology technique.Clinical anatomy (New York, N.Y.) · 2023Article
- X-ray Microtomography to Assess Determinants of In Vivo N-Butyl Cyanoacrylate GlubranBiomedicines · 2022Article
- Three-dimensional anatomy of the Denonvilliers' fascia after micro-CT reconstruction.Scientific reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Manual dissection and histologic examination are commonly used to investigate human structures, but there are limitations in the damage caused to delicate structures or the provision of limited information. Micro-computed tomography (microCT) enables a three-dimensional volume-rendered observation of the sample without destruction and deformation, but it can only visualize hard tissues in general. Therefore, contrast-enhancing agents are needed to help in visualizing soft tissue. This study aimed to introduce microCT with phosphotungstic acid preparation (PTA-microCT) by applying the method to different types of human tissue. Specimens from human cadavers were used to examine the orbicularis retaining ligament (ORL), nasolabial fold (NLF), and the calcaneal tunnel of the sole. Using PTA-microCT, relevant information of human structures was identified. In the ORL study, tiny and delicate ligamentous fibers were visualized in detail with multidirectional continuity. In the NLF study, complex structural formation consisting of various types of soft tissue were investigated comprehensively. In the calcaneal tunnel study, the space surrounded by diverse features and its inner vulnerable structures were examined without damage. Consequently, we successfully applied the PTA-microCT technique to the analysis of specific human soft tissue structures that are challenging to analyze by conventional methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.