ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022
Progression of optic atrophy in traumatic optic neuropathy: retrograde neuronal degeneration in humans.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Neuroprotective Effect of Methylene Blue in a Rat Model of Traumatic Optic Neuropathy.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Intraretinal microvascular alterations in indirect traumatic optic neuropathy using optical coherence tomography angiography.Eye (London, England) · 2024Article
- Effects of light perception on visual function recovery in patients with traumatic optic neuropathy.Scientific reports · 2024Article
- BDNF and cAMP are neuroprotective in a porcine model of traumatic optic neuropathy.JCI insight · 2024Article
- Association between retinal thickness and disease characteristics in adult epilepsy: A cross-sectional OCT evaluation.Epilepsia open · 2024Article
- Clinical efficacy of optical coherence tomography parameters to predict the visual field outcome following pituitary adenoma surgery.PloS one · 2024Article
- Modifications in Macular Perfusion and Neuronal Loss After Acute Traumatic Brain Injury.Investigative ophthalmology & visual science · 2023Observational
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5 authors at 2 institutions in 1 country.
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Abstract
objectiveWe used optical coherence tomography (OCT) to document the time course of retrograde neuronal degeneration following indirect optic nerve injury.
methodsWe retrospectively studied patients diagnosed with unilateral indirect traumatic optic neuropathy (TON). Patients with total or near-total optic atrophy were included. All patients underwent complete ophthalmological examinations, including OCT imaging, within 1 day and at 1, 2, 3, 4, 6, 8, 12, 24, and 48 weeks after trauma.
resultsThe mean thicknesses of the circumpapillary retinal nerve fiber layer (cpRNFL) and macular retinal ganglion cell-inner plexiform layer (mGCIPL) decreased significantly at 2 weeks after trauma (p = 0.027 and p = 0.043). Changes in mGCIPL thickness preceded changes in cpRNFL thickness. The rates of reduction in mGCIPL and cpRNFL thicknesses were greatest between 2 to 4 weeks and 4 to 6 weeks after trauma. The reduction in mGCIPL thickness then slowed, and stabilized at 12 weeks after trauma. The proportions of cpRNFL and mGCIPL losses at 2, 4, 6, 8, and 12 weeks compared to 24 weeks were 17.1, 33.7, 59.8, 77.9, and 87.9% and 30.0, 73.3, 76.1, 88.3, and 97.9%, respectively.
conclusionsOCT revealed optic atrophy progression 2 weeks after trauma, which was most rapid from 2 to 6 weeks, and then gradually stabilized. Loss of retinal ganglion cell bodies and dendrites seemed to precede the axonal degeneration. Observations of morphological changes in retinal layers using OCT in TON patients improve our understanding of retrograde neuronal degeneration of the central nervous system.
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