ArticleCirculation. Genomic and precision medicine2021
Multiethnic Genome-Wide Association Study of Subclinical Atherosclerosis in Individuals With Type 2 Diabetes.
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Article in Circulation. Genomic and precision medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Circulating MicroRNA Profiling Identifies Distinct MicroRNA Signatures in Acute Ischemic Stroke and Transient Ischemic Attack Patients.International journal of molecular sciences · 2022Trial
- Hexosamine Biosynthetic Pathway and Fatty Acid β-Oxidative Imbalance: A Key Mechanism by Which Abnormal Macrophage Lipophagy Promotes Atherosclerosis in Diabetes.Cardiovascular drugs and therapy · 2026Review
- Insights into the molecular underpinning of type 2 diabetes complications.Human molecular genetics · 2025Review
- Subclinical Atherosclerosis to Guide Treatment in Dyslipidemia and Diabetes Mellitus.Current atherosclerosis reports · 2024Review
- Matrix Gla protein polymorphism rs1800802 is associated with atheroma plaque progression and with cardiovascular events in a chronic kidney disease cohort.Clinical kidney journal · 2024Article
- Artificial Intelligence in Cardiology and Atherosclerosis in the Context of Precision Medicine: A Scoping Review.Applied bionics and biomechanics · 2024Article
- Review
- Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis.Circulation. Genomic and precision medicine · 2023Article
Corrections and comments
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Authors and funding
42 authors at 14 institutions in 4 countries.
Yingchang LuDivision of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (Y.L., M.C.Y.N.).
Latchezar DimitrovCenter for Precision Medicine (L.D., C.D.L., D.W.B., M.C.Y.N.), Wake Forest School of Medicine, Winston-Salem, NC.
Shyh-Huei ChenDepartment of Biostatistics and Data Science (S.-H.C., L.L., C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Lawrence F BielakDepartment of Epidemiology (L.F.B., S.L.R.K., P.A.P.).
Joshua C BisCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services (J.C.B.), University of Washington, Seattle.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Farrell Learning Center, St Louis, MO (M.F.F., L.W., J.Z., P.A.).
Lingyi LuDepartment of Biostatistics and Data Science (S.-H.C., L.L., C.D.L.), Wake Forest School of Medicine, Winston-Salem, NC.
Maryam KavousiDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands (M.K., D.B., M.G., M.A.I., A.G.U.).
Laura M RaffieldDepartment of Genetics (L.M.R.), University of North Carolina, Chapel Hill.
Albert V SmithDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI (A.V.S.).
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Farrell Learning Center, St Louis, MO (M.F.F., L.W., J.Z., P.A.).
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald, Germany (S.W.).
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., K.D.T., X.G., J.I.R.).
Jiaxi ZhuDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Farrell Learning Center, St Louis, MO (M.F.F., L.W., J.Z., P.A.).
Elias F GudmundssonFaculty of Medicine, University of Iceland, Reykjavik (A.V.S., E.F.G., V.G., G.K.G., V.G.G.).
Valborg GudmundsdottirFaculty of Medicine, University of Iceland, Reykjavik (A.V.S., E.F.G., V.G., G.K.G., V.G.G.).
Daniel BosDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands (M.K., D.B., M.G., M.A.I., A.G.U.).
Mohsen GhanbariDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands (M.K., D.B., M.G., M.A.I., A.G.U.).
M Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands (M.K., D.B., M.G., M.A.I., A.G.U.).
Shih-Jen HwangThe Population Sciences Branch, Division of Intramural Research (S.-J.H), National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., K.D.T., X.G., J.I.R.).
Matthew J BudoffDivision of Cardiology, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA (M.J.B.).
Gauti K GíslasonFaculty of Medicine, University of Iceland, Reykjavik (A.V.S., E.F.G., V.G., G.K.G., V.G.G.).
Christopher J O'DonnellVA Boston Healthcare System (C.J.O.), Harvard Medical School, Boston, MA.
Ping AnDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, Farrell Learning Center, St Louis, MO (M.F.F., L.W., J.Z., P.A.).
Nora FranceschiniDepartment of Epidemiology (N.F., G.H.), University of North Carolina, Chapel Hill.
Barry I FreedmanDepartment of Internal Medicine (B.I.F.), Wake Forest School of Medicine, Winston-Salem, NC.
Yi-Ping FuOffice of Biostatistics Research (Y.-P.F.), National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., K.D.T., X.G., J.I.R.).
Gerardo HeissDepartment of Epidemiology (N.F., G.H.), University of North Carolina, Chapel Hill.
Sharon L R KardiaDepartment of Epidemiology (L.F.B., S.L.R.K., P.A.P.).
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (J.G.W.).
Carl D LangefeldCenter for Precision Medicine (L.D., C.D.L., D.W.B., M.C.Y.N.), Wake Forest School of Medicine, Winston-Salem, NC.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Germany (U.S.).
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands (M.K., D.B., M.G., M.A.I., A.G.U.).
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora (L.A.L.).
Patricia A PeyserDepartment of Epidemiology (L.F.B., S.L.R.K., P.A.P.).
Vilmundur G GudnasonFaculty of Medicine, University of Iceland, Reykjavik (A.V.S., E.F.G., V.G., G.K.G., V.G.G.).
Bruce M PsatyDepartments of Epidemiology and Health Services (B.M.P.), University of Washington, Seattle.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.Y., K.D.T., X.G., J.I.R.).
Donald W BowdenCenter for Precision Medicine (L.D., C.D.L., D.W.B., M.C.Y.N.), Wake Forest School of Medicine, Winston-Salem, NC.
Maggie C Y NgDivision of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN (Y.L., M.C.Y.N.).
Wake Forest University · USErasmus MC · NLGfK (United States) · USUCLA Medical Center · USWashington University in St. Louis · USUniversity of North Carolina at Chapel Hill · USNational Heart Lung and Blood Institute · USUniversitätsmedizin Greifswald · DEBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USDepartment of Health Services · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Washington · USVanderbilt University Medical Center · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWORKER PROTECTION AGAINST AIRBORNE INFLUENZA - A PILOT STUDYM01RR007122 · NCRR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KOCH, KENNETH L · 1992 to 2010
$35.2MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
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Abstract
backgroundCoronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an independent cardiovascular disease risk factor that accelerates atherosclerosis.
methodsWe performed meta-analyses of genome-wide association studies in up to 2500 T2D individuals of European ancestry (EA) and 1590 T2D individuals of African ancestry with or without exclusion of prevalent cardiovascular disease, for CAC measured by cardiac computed tomography, and 3608 individuals of EA and 838 individuals of African ancestry with T2D for cIMT measured by ultrasonography within the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) Consortium.
resultsWe replicated 2 loci (rs9369640 and rs9349379 near
conclusionsOur results provide potential biological mechanisms that could link CAC and cIMT to increased cardiovascular disease risk in individuals with T2D.
Indexed as
Genetic LociGenetic Predisposition to DiseaseAtherosclerosisBlack PeopleDiabetes ComplicationsDiabetes Mellitus, Type 2Genome-Wide Association StudyHumansWhite Peopleatherosclerosiscarotid intima-media thicknesscoronary artery diseasegeneticsgenome-wide association study
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