Evidence map›Paper›PMID 34241389›Full record

ArticleThe Journal of chemical physics2021

Multiscale modeling of genome organization with maximum entropy optimization.

Xingcheng Lin, Yifeng Qi, Andrew P Latham, Bin Zhang

Abstract read
In one paragraph

Article in The Journal of chemical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Reversing aging-like 3D genome disorganization in abioRxiv : the preprint server for biology · 2026
    Article
  2. Article
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  6. Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Review
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  15. Tutorial on integrative spatiotemporal modeling by integrative modeling platform.Protein science : a publication of the Protein Society · 2025
    Article
  16. Article
  17. Energy landscape analysis of the development of the chromosome structure across the cell cycle.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Integrative spatiotemporal modeling of biomolecular processes: Application to the assembly of the nuclear pore complex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xingcheng LinDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000000293786174
Yifeng QiDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Andrew P LathamDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000000293387253
Bin ZhangDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.ORCID 0000000236857503

Funding

Probing and Perturbing Transcriptional Condensates with Multiscale Modeling and Deep LearningR35GM133580 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Bin Zhang · 2019 to 2026
$3.1M
NIGMS NIH HHS R35 GM133580
6 · The paper itself

Abstract

Three-dimensional (3D) organization of the human genome plays an essential role in all DNA-templated processes, including gene transcription, gene regulation, and DNA replication. Computational modeling can be an effective way of building high-resolution genome structures and improving our understanding of these molecular processes. However, it faces significant challenges as the human genome consists of over 6 × 10

Indexed as

EntropyModels, GeneticAlgorithmsDNAHumansMolecular Dynamics SimulationDNA

Identifiers

PMID34241389
PMCPMC8253599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.