ArticleeLife2021
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection.
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In one paragraph
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
What it found
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Cell autonomous inflammation in VEXAS is mediated by cGAS-STING.bioRxiv : the preprint server for biology · 2026Article
- Functional integrity of the SEL1L-HRD1 complex is critical for endoplasmic reticulum-associated degradation and organismal viability.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- SEL1L-HRD1-mediated ERAD in mammals.Nature cell biology · 2025Review
- Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy.Trends in cell biology · 2025Review
- The impact of SEC23A on 5-FU chemotherapy sensitivity and its involvement in endoplasmic reticulum stress-induced apoptosis in colorectal cancer.Apoptosis : an international journal on programmed cell death · 2025Article
- Endoplasmic reticulum-associated degradation mitigates atherosclerosis by maintaining cellular homeostasis.Frontiers in physiology · 2025Review
- Food for thought: Nutrient metabolism controlling early T cell development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Purkinje cell-specific deficiency in SEL1L-hrd1 endoplasmic reticulum-associated degradation causes progressive cerebellar ataxia in mice.JCI insight · 2024Article
- ER-associated degradation adapter Sel1L is required for CD8Cell reports · 2024Article
- SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex.Nature communications · 2024Article
- Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis.Nature communications · 2024Article
- Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery.The Journal of clinical investigation · 2024Article
- Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.The Journal of clinical investigation · 2024Article
- Biallelic Cys141Tyr variant of SEL1L is associated with neurodevelopmental disorders, agammaglobulinemia, and premature death.The Journal of clinical investigation · 2024Article
- Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection.Frontiers in immunology · 2024Article
- SEL1L preserves CD8Cellular & molecular immunology · 2023Article
- Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors.Science (New York, N.Y.) · 2023Article
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- SEL1L-HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool.Nature cell biology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Xia Liu *Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Jingjing Yu *Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-2408-5809
Longyong Xu *Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-8574-4062
Katharine Umphred-Wilson *Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, United States.ORCID 0000-0001-6416-0466
Fanglue PengDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Yao DingDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Brendan M BartonDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, United States.
Xiangdong LvDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Michael Y ZhaoDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.
Shengyi SunCenter for Molecular Medicine and Genetics, Wayne State University, Detroit, United States.
Yuning HongDepartment of Chemistry and Physics, La Trobe University, Melbourne, Australia.
Ling QiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, United States.
Stanley AdoroDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, United States.
Xi ChenDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-7995-6202
Baylor College of Medicine · USCase Western Reserve University · USLa Trobe University · AUUniversity of Michigan · USWayne State University · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI James Versalovic · 2001 to 2026
$28.3MTranslational Research in Breast Cancer (SPORE)P50CA186784 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATTHEW J ELLIS · 2014 to 2026
$24.5MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MGRADUATE TRAINING IN CELLULAR AND MOLECULAR BIOLOGYT32GM008056 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI DIEHL, JOHN ALAN, SNIDER, MARTIN D · 1985 to 2019
$7.1MMechanism and Function of Endoplasmic Reticulum Protein Quality Control Machinery In The Maintenance of Hematopoietic Stem CellsR01HL146642 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, XI · 2019 to 2023
$2.5MCrosstalk Between the ER Stress Response and Mitochondrial Fatty Acid Oxidation in MYC-driven Breast CancerR37CA228304 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHEN, XI · 2018 to 2024
$2.5MRegulation of Mitochondrial Dynamics by ERAD: Administrative SupplementR35GM130292 · NIGMS · UNIVERSITY OF VIRGINIA · PI QI, LING · 2019 to 2023
$2.5MMechanisms of tunable posttranslational control of T-cell homeostasis and toleranceR01AI143992 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI XIAO, TSAN SAM · 2019 to 2023
$2.2MUnion Biometrica BioSorterS10OD025251 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEETON, CHRISTINE · 2018 to 2018
$600kBD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430kNCI NIH HHS K22 CA218467NCI NIH HHS P30 CA125123NCI NIH HHS P50 CA186784NCI NIH HHS R37 CA228304NCRR NIH HHS S10 RR024574NHLBI NIH HHS R01 HL146642NIAID NIH HHS R01 AI143992NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285NIGMS NIH HHS R35 GM130292NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM008056NIH HHS S10 OD025251
Abstract
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4
Indexed as
AnimalsEndoplasmic Reticulum-Associated DegradationEndoplasmic Reticulum StressEndoribonucleasesFemaleInflammationIntracellular Signaling Peptides and ProteinsMiceMice, Inbred C57BLProtein Serine-Threonine KinasesProteostasisReceptors, NotchThymocytesUbiquitin-Protein LigasesX-Box Binding Protein 1EndoribonucleasesErn1 protein, mouseIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesReceptors, NotchSel1h protein, mouseSyvn1 protein, mouseUbiquitin-Protein LigasesX-Box Binding Protein 1Xbp1 protein, mousebeta-selectiondevelopmental biologyER-associated degradationER stressimmunologyinflammationmouseproteostasisthymocytes
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.