ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2022
Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- Hierarchical Gene Cluster Regulation Across Vertebrate Skins: Developmental Control of Keratin Gene Expression.bioRxiv : the preprint server for biology · 2026Article
- The Epithelial Egg Tooth of the Chicken Shares Protein Markers with the Embryonic Subperiderm and Feathers.Journal of developmental biology · 2025Article
- Genome-Wide Association Studies in Japanese Quails of the FInternational journal of molecular sciences · 2025Article
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Analysis and comparison of protein secondary structures in the rachis of avian flight feathers.PeerJ · 2022Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundAnimals develop skin regional specificities to best adapt to their environments. Birds are excellent models in which to study the epigenetic mechanisms that facilitate these adaptions. Patients suffering from SATB2 mutations exhibit multiple defects including ectodermal dysplasia-like changes. The preferential expression of SATB2, a chromatin regulator, in feather-forming compared to scale-forming regions, suggests it functions in regional specification of chicken skin appendages by acting on either differentiation or morphogenesis.
resultsRetrovirus mediated SATB2 misexpression in developing feathers, beaks, and claws causes epidermal differentiation abnormalities (e.g. knobs, plaques) with few organ morphology alterations. Chicken β-keratins are encoded in 5 sub-clusters (Claw, Feather, Feather-like, Scale, and Keratinocyte) on Chromosome 25 and a large Feather keratin cluster on Chromosome 27. Type I and II α-keratin clusters are located on Chromosomes 27 and 33, respectively. Transcriptome analyses showed these keratins (1) are often tuned up or down collectively as a sub-cluster, and (2) these changes occur in a temporo-spatial specific manner.
conclusionsThese results suggest an organizing role of SATB2 in cluster-level gene co-regulation during skin regional specification.
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