ArticleProteins2021
Topology evaluation of models for difficult targets in the 14th round of the critical assessment of protein structure prediction (CASP14).
Article in Proteins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed.
- The latest AI breakthroughs in structural biology: protein binder design and conformational state prediction.Communications biology · 2026Article
- Family-level specialization in protein domain insertion architectures.Protein science : a publication of the Protein Society · 2026Article
- Predicting Single-Stranded DNA Oligonucleotides 3D Structures: An Open Issue.Computational and structural biotechnology journal · 2026Article
- CASP16 Protein Monomer Structure Prediction Assessment.Proteins · 2026Article
- From CASP13 to the Nobel Prize: DeepMind's AlphaFold Journey in Revolutionizing Protein Structure Prediction and Beyond.Current protein & peptide science · 2026Review
- Assessment of Nucleic Acid Structure Prediction in CASP16.Proteins · 2026Article
- Assessment of nucleic acid structure prediction in CASP16.bioRxiv : the preprint server for biology · 2025Article
- The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insights into virulence: structure classification of themSystems · 2023Article
- Tertiary structure assessment at CASP15.Proteins · 2023Article
- Article
- Assessment of three-dimensional RNA structure prediction in CASP15.bioRxiv : the preprint server for biology · 2023Article
- A gated graph transformer for protein complex structure quality assessment and its performance in CASP15.Bioinformatics (Oxford, England) · 2023Article
- Classification of domains in predicted structures of the human proteome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- DPAM: A domain parser for AlphaFold models.Protein science : a publication of the Protein Society · 2023Article
- Article
- Protein Design: From the Aspect of Water Solubility and Stability.Chemical reviews · 2022Review
- Dali server: structural unification of protein families.Nucleic acids research · 2022Article
- Co-component signal transduction systems: Fast-evolving virulence regulation cassettes discovered in enteric bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
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5 authors.
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Abstract
This report describes the tertiary structure prediction assessment of difficult modeling targets in the 14th round of the Critical Assessment of Structure Prediction (CASP14). We implemented an official ranking scheme that used the same scores as the previous CASP topology-based assessment, but combined these scores with one that emphasized physically realistic models. The top performing AlphaFold2 group outperformed the rest of the prediction community on all but two of the difficult targets considered in this assessment. They provided high quality models for most of the targets (86% over GDT_TS 70), including larger targets above 150 residues, and they correctly predicted the topology of almost all the rest. AlphaFold2 performance was followed by two manual Baker methods, a Feig method that refined Zhang-server models, two notable automated Zhang server methods (QUARK and Zhang-server), and a Zhang manual group. Despite the remarkable progress in protein structure prediction of difficult targets, both the prediction community and AlphaFold2, to a lesser extent, faced challenges with flexible regions and obligate oligomeric assemblies. The official ranking of top-performing methods was supported by performance generated PCA and heatmap clusters that gave insight into target difficulties and the most successful state-of-the-art structure prediction methodologies.
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