Evidence map›Paper›PMID 34240317›Full record

ArticleAIDS and behavior2021

Qualitative Assessment of Barriers and Facilitators of PrEP Use Before and After Rollout of a PrEP Program for Priority Populations in South-central Uganda.

William Ddaaki, Susanne Strömdahl, Ping Teresa Yeh, Joseph G Rosen, Jade Jackson, Neema Nakyanjo, Joseph Kagaayi, Godfrey Kigozi, Gertrude Nakigozi, M Kathryn Grabowski and 5 more

Abstract read
In one paragraph

Article in AIDS and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

William Ddaaki *Rakai Health Sciences Program, Kalisizo, Uganda.
Susanne Strömdahl *Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Ping Teresa Yeh *Social and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., E5547, Baltimore, MD, 21205, USA.
Joseph G RosenSocial and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., E5547, Baltimore, MD, 21205, USA.
Jade JacksonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Neema NakyanjoRakai Health Sciences Program, Kalisizo, Uganda.
Joseph KagaayiRakai Health Sciences Program, Kalisizo, Uganda.
Godfrey KigoziRakai Health Sciences Program, Kalisizo, Uganda.
Gertrude NakigoziRakai Health Sciences Program, Kalisizo, Uganda.
M Kathryn GrabowskiDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Larry W ChangSocial and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., E5547, Baltimore, MD, 21205, USA.
Steven J ReynoldsRakai Health Sciences Program, Kalisizo, Uganda.
Fred NalugodaRakai Health Sciences Program, Kalisizo, Uganda.
Anna Mia Ekström *Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.
Caitlin E Kennedy *Social and Behavioral Interventions Program, Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., E5547, Baltimore, MD, 21205, USA. caitlinkennedy@jhu.edu.ORCID http://orcid.org/0000-0001-6820-063X

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
Synthesizing HIV Behavioral Intervention Effectiveness in Developing CountriesR01MH090173 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SWEAT, MICHAEL D · 2010 to 2019
$4.2M
CHWs, mHealth, and Combination HIV Prevention in a Hotspot: A Randomized TrialR01MH107275 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2015 to 2019
$2.7M
Hard-to-Reach Populations: Implications for Ending the AIDS EpidemicR01AI143333 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2019 to 2022
$2.4M
Multidisciplinary Research Training to Understand and Reduce HIV Incidence in UgandaD43TW010557 · FIC · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2018 to 2022
$1.6M
FIC NIH HHS D43 TW010557FIC NIH HHS D43TW010557JHU Center for AIDS Research P30AI094189national institute of allergy and infectious diseases R01AI143333NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI143333NIMH NIH HHS R01 MH090173NIMH NIH HHS R01MH090173, R01MH107275NIMH NIH HHS R01 MH107275
6 · The paper itself

Abstract

Uganda piloted HIV pre-exposure prophylaxis (PrEP) for priority populations (sex workers, fishermen, truck drivers, discordant couples) in 2017. To assess facilitators and barriers to PrEP uptake and adherence, we explored perceptions of PrEP before and experiences after rollout among community members and providers in south-central Uganda. We conducted 75 in-depth interviews and 12 focus group discussions. We analyzed transcripts using a team-based thematic framework approach. Partners, family, peers, and experienced PrEP users provided adherence support. Occupational factors hindered adherence for sex workers and fishermen, particularly related to mobility. Pre-rollout concerns about unskilled/untrained volunteers distributing PrEP and price-gouging were mitigated. After rollout, awareness of high community HIV risk and trust in PrEP effectiveness facilitated uptake. PrEP stigma and unexpected migration persisted as barriers. Community-initiated, tailored communication with successful PrEP users may optimize future engagement by addressing fears and rumors, while flexible delivery and refill models may facilitate PrEP continuation and adherence.

Indexed as

Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisSex WorkersHumansUgandaAnti-HIV AgentsFishing communitiesImplementation sciencePre-exposure prophylaxisSex workersUganda

Identifiers

PMID34240317
PMCPMC8603943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.