Evidence map›Paper›PMID 34240245›Full record

ArticleLung2021

Diastolic Dysfunction Contributes to Impaired Cardiorespiratory Fitness in Patients with Lung Cancer and Reduced Lung Function Following Chest Radiation.

Georgia K Thomas, Cory R Trankle, Salvatore Carbone, Hayley Billingsley, Benjamin W Van Tassell, Ronald K Evans, Ryan Garten, Elisabeth Weiss, Antonio Abbate, Justin M Canada

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Georgia K ThomasDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA. georgia.thomas@vcuhealth.org.ORCID http://orcid.org/0000-0002-8303-258X
Cory R TrankleDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Salvatore CarboneDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Hayley BillingsleyDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Benjamin W Van TassellDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Ronald K EvansDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Ryan GartenDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, VA, USA.
Elisabeth WeissDepartment of Radiation Oncology, VCU Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA.
Antonio AbbateDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Justin M CanadaDepartment of Internal Medicine, Virginia Commonwealth University, PO Box 980102, Richmond, VA, USA.
Virginia Commonwealth University · US

Funding

Virus Vector Shared ResourceP30CA016059 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Kim Felder Rhoads · 1985 to 2026
$51.0M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
Endothelial Dysfunction in Radiation-induced Lung and Heart ToxicityU01AI133595 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI YAKOVLEV, VASILY · 2017 to 2021
$2.2M
NCATS NIH HHS UL1 TR002649NCI NIH HHS P30 CA016059NIAID NIH HHS U01 AI133595
6 · The paper itself

Abstract

Cardiorespiratory fitness (CRF) is a robust and independent predictor of cardiovascular health and overall mortality. Patients with lung cancer often have chronic lung disease, contributing to impaired CRF. Radiation to the heart during lung cancer treatment may further reduce CRF. The determinants of CRF in this population are not well understood. We prospectively evaluated 12 patients with lung cancer without known cardiovascular disease with reduced lung function receiving curative intent thoracic radiotherapy to determine whether cardiac diastolic function, as assessed by Doppler echocardiography and N-terminal pro-brain natriuretic peptide (NTproBNP) levels, correlate with CRF measured by peak oxygen consumption (VO

Indexed as

Cardiorespiratory FitnessLung NeoplasmsDiastoleEchocardiography, DopplerHumansLungOxygen ConsumptionCardiorespiratory fitnessLung cancerN-terminal pro-brain natriuretic peptideRadiotherapy

Identifiers

PMID34240245
PMCPMC8627110
OpenAlexW3163200084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.