ArticleThe Plant cell2021
Defects in meiotic chromosome segregation lead to unreduced male gametes in Arabidopsis SMC5/6 complex mutants.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Newly unveiled meiosis elucidates the unreduced gamete frequency and its impact on the evolution of the Lemna minor complex.Journal of experimental botany · 2026Article
- Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana.Planta · 2026Article
- ClPS1 gene-mediated manipulation of 2n pollen formation enables the creation of triploid seedless watermelon.Molecular horticulture · 2025Article
- Polyploid Formation Through Disrupting Mitotic Sister Chromatid Separation of Spermatogonia based on espl1 Heterozygous Knockout in Fish.Molecular biology and evolution · 2025Article
- Analysis of Meiotic Behavior and 2n Pollen Formation Frequency in Triploid Hybrids of Chinese Jujube.Plants (Basel, Switzerland) · 2025Article
- The interplay of homology-directed repair pathways in the repair of zebularine-induced DNA-protein crosslinks in Arabidopsis.The Plant journal : for cell and molecular biology · 2024Article
- The Promising Potential of Triploidy in Date Palm (Plants (Basel, Switzerland) · 2024Article
- Transition from sexuality to androgenesis through a meiotic modification during spermatogenesis in freshwater Corbicula clams.PloS one · 2024Article
- The multi-functional Smc5/6 complex in genome protection and disease.Nature structural & molecular biology · 2023Review
- The scaffold nucleoporins SAR1 and SAR3 are essential for proper meiotic progression inFrontiers in cell and developmental biology · 2023Article
- Multiple Roles of SMC5/6 Complex during Plant Sexual Reproduction.International journal of molecular sciences · 2022Review
- The INDEPTH (Impact of Nuclear Domains on Gene Expression and Plant Traits) Academy: a community resource for plant science.Journal of experimental botany · 2022Article
- Editorial: Meiotic Recombination and DNA Repair: New Approaches to Solve Old Questions in Model and Non-model Plant Species.Frontiers in plant science · 2022Article
- Exploiting Unreduced Gametes for Improving Ornamental Plants.Frontiers in plant science · 2022Review
- The SUMO ligase MMS21 profoundly influences maize development through its impact on genome activity and stability.PLoS genetics · 2021Article
- Structural Maintenance of Chromosomes 5/6 Complex Is Necessary for Tetraploid Genome Stability inFrontiers in plant science · 2021Article
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural maintenance of chromosome 5/6 (SMC5/6) complex is a crucial factor for preserving genome stability. Here, we show that mutants for several Arabidopsis (Arabidopsis thaliana) SMC5/6 complex subunits produce triploid offspring. This phenotype is caused by a meiotic defect leading to the production of unreduced male gametes. The SMC5/6 complex mutants show an absence of chromosome segregation during the first and/or the second meiotic division, as well as a partially disorganized microtubule network. Importantly, although the SMC5/6 complex is partly required for the repair of SPO11-induced DNA double-strand breaks, the nonreduction described here is SPO11-independent. The measured high rate of ovule abortion suggests that, if produced, such defects are maternally lethal. Upon fertilization with an unreduced pollen, the unbalanced maternal and paternal genome dosage in the endosperm most likely causes seed abortion observed in several SMC5/6 complex mutants. In conclusion, we describe the function of the SMC5/6 complex in the maintenance of gametophytic ploidy in Arabidopsis.
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