ArticleCerebral cortex (New York, N.Y. : 1991)2021
Obese Individuals Show Disrupted Dynamic Functional Connectivity between Basal Ganglia and Salience Networks.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Body weight-related alterations in white matter functional connectivity in children: An fMRI study.BMC neurology · 2026Article
- Characterizing the relationship between functional network dynamics and the body mass index.Frontiers in nutrition · 2026Article
- Central Obesity Disrupts Brain Network Organization in Aging via Metabolic and Structural Pathways.Aging and disease · 2025Article
- Aberrant brain network connectivity related to cognitive and emotional regulation in women with abdominal obesity.Scientific reports · 2025Article
- Cachexia Alters Central Nervous System Morphology and Functionality in Cancer Patients.Journal of cachexia, sarcopenia and muscle · 2025Article
- Cerebellocerebral connectivity predicts body mass index: a new open-source Python-based framework for connectome-based predictive modeling.GigaScience · 2025Article
- Brain network dynamics associated with intentional weight loss in older adults.Aperture neuro · 2025Article
- Aberrant dynamic functional network connectivity in type 2 diabetes mellitus individuals.Cognitive neurodynamics · 2023Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- The body mass index is associated with increased temporal variability of functional connectivity in brain reward system.Frontiers in nutrition · 2023Article
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
Previous functional magnetic resonance imaging (fMRI) studies have showed obesity (OB)-related alterations in intrinsic functional connectivity (FC) within and between different resting-state networks (RSNs). However, few studies have examined dynamic functional connectivity (DFC). Thus, we employed resting-state fMRI with independent component analysis (ICA) and DFC analysis to investigate the alterations in FC within and between RSNs in 56 individuals with OB and 46 normal-weight (NW) controls. ICA identified six RSNs, including basal ganglia (BG), salience network (SN), right executive control network/left executive control network, and anterior default-mode network (aDMN)/posterior default-mode network. The DFC analysis identified four FC states. OB compared with NW had more occurrences and a longer mean dwell time (MDT) in state 2 (positive connectivity of BG with other RSN) and also had higher FC of BG-SN in other states. Body mass index was positively correlated with MDT and FCs of BG-aDMN (state 2) and BG-SN (state 4). DFC analysis within more refined nodes of RSNs showed that OB had more occurrences and a longer MDT in state 1 in which caudate had positive connections with the other network nodes. The findings suggest an association between caudate-related and BG-related positive FC in OB, which was not revealed by traditional FC analysis, highlighting the utility of adding DFC to the more conventional methods.
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