ReviewBrain : a journal of neurology2021
Evidence and implications of abnormal predictive coding in dementia.
Review in Brain : a journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 3 citations in OpenAlex.
- Neuroimaging Meta-Analyses Reveal Convergence of Interoception, Emotion, and Social Cognition Across Neurodegenerative Diseases.Biological psychiatry · 2025Pooled it
- A systematic review on resting state functional connectivity in patients with neurodegenerative disease and hallucinations.NeuroImage. Clinical · 2022Pooled it
- Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.PLoS computational biology · 2022Trial
- Anticipatory slow potentials before auditory feedback show posterior predominance but limited condition effects in speech-in-noise.IBRO neuroscience reports · 2026Article
- Dopamine Compensates for Amyloid-Induced Default Mode Network Dysfunction to Support Learning.bioRxiv : the preprint server for biology · 2026Article
- Do auditory deviants evoke cortical state changes under anaesthesia? A proof-of-concept study.Experimental physiology · 2026Article
- Uncertainty as an operative construct and treatment target in functional neurological disorder.Frontiers in psychiatry · 2026Article
- Blood-Based Biomarkers for Traumatic Brain Injury: A New Era in Diagnosis and Prognosis.International journal of molecular sciences · 2025Review
- Misclassification in memory modification ineLife · 2025Article
- Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- Development of a Self-Report Measure of Prediction in Daily Life: The Prediction-Related Experiences Questionnaire.Journal of autism and developmental disorders · 2025Article
- Sleep Deprivation and Alzheimer's Disease: A Review of the Bidirectional Interactions and Therapeutic Potential of Omega-3.Brain sciences · 2025Review
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.Brain : a journal of neurology · 2024Review
- Sensory Loss and Risk of Dementia.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Article
- Alzheimer disease may compromise patients' ability for expectancy-based pain modulation. Now what?Pain · 2024Article
- Intrinsic timescales and predictive allostatic interoception in brain health and disease.Neuroscience and biobehavioral reviews · 2024Review
- Frontotemporal lobar degeneration changes neuronal beta-frequency dynamics during the mismatch negativity response.NeuroImage. Clinical · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
The diversity of cognitive deficits and neuropathological processes associated with dementias has encouraged divergence in pathophysiological explanations of disease. Here, we review an alternative framework that emphasizes convergent critical features of cognitive pathophysiology. Rather than the loss of 'memory centres' or 'language centres', or singular neurotransmitter systems, cognitive deficits are interpreted in terms of aberrant predictive coding in hierarchical neural networks. This builds on advances in normative accounts of brain function, specifically the Bayesian integration of beliefs and sensory evidence in which hierarchical predictions and prediction errors underlie memory, perception, speech and behaviour. We describe how analogous impairments in predictive coding in parallel neurocognitive systems can generate diverse clinical phenomena, including the characteristics of dementias. The review presents evidence from behavioural and neurophysiological studies of perception, language, memory and decision-making. The reformulation of cognitive deficits in terms of predictive coding has several advantages. It brings diverse clinical phenomena into a common framework; it aligns cognitive and movement disorders; and it makes specific predictions on cognitive physiology that support translational and experimental medicine studies. The insights into complex human cognitive disorders from the predictive coding framework may therefore also inform future therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.