Evidence map›Paper›PMID 34239893›Full record

ArticleFrontiers in molecular biosciences2021

Large-Scale Computational Discovery of Binding Motifs in tRNA Fragments.

Lingyu Guan, Vincent Lam, Andrey Grigoriev

Abstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Transfer RNA Fragments in Diseases of Sensory Organs.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Transfer RNA and Origins of RNA Interference.Frontiers in molecular biosciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lingyu GuanDepartment of Biology, Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States.
Vincent LamDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States.
Andrey GrigorievDepartment of Biology, Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, United States.

Funding

Variant identification for cancer genomicsR15CA220059 · NCI · RUTGERS THE STATE UNIV OF NJ CAMDEN · PI GRIGORIEV, ANDREY · 2018 to 2018
$447k
NCI NIH HHS R15 CA220059
6 · The paper itself

Abstract

Accumulating evidence has suggested that tRNA-derived fragments (tRFs) could be loaded to Argonaute proteins and function as regulatory small RNAs. However, their mode of action remains largely unknown, and investigations of their binding mechanisms have been limited, revealing little more than microRNA-like seed regions in a handful of tRFs and a few targets. Here, we identified such regions of potential interaction on a larger scale, using

Indexed as

Argonautebinding motiftarget genestRNAtRNA fragments

Identifiers

PMID34239893
PMCPMC8258673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.