Evidence map›Paper›PMID 34239862›Full record

ReviewFrontiers in bioengineering and biotechnology2021

Large-Scale

Li-Fu Song, Zheng-Hua Deng, Zi-Yi Gong, Lu-Lu Li, Bing-Zhi Li

Abstract readReview
In one paragraph

Review in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. PlantGFM: A Genomic Foundation Model for Discovery and Creation of Plant Genes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. A Physics-Inspired Approach to Improve Oligonucleotide Design and Gene Synthesis.Computational and structural biotechnology journal · 2026
    Article
  4. Article
  5. Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Article
  7. Review
  8. CertPrime: a new oligonucleotide design tool for gene synthesis.Computational and structural biotechnology journal · 2025
    Article
  9. DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Codon-optimization in gene therapy: promises, prospects and challenges.Frontiers in bioengineering and biotechnology · 2024
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. DNA Data Storage.Biotech (Basel (Switzerland)) · 2023
    Review
  16. Article
  17. Assessment of enzymatically synthesized DNA for gene assembly.Frontiers in bioengineering and biotechnology · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Li-Fu SongFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.
Zheng-Hua DengFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.
Zi-Yi GongFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.
Lu-Lu LiLC-BIO Technologies Co., Ltd., Hangzhou, China.
Bing-Zhi LiFrontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decades, remarkable progress on phosphoramidite chemistry-based large-scale

Indexed as

data storage in DNADNA-based data storageDNA synthesisoligonucleotide synthesissynthetic biologywhole-genome synthesis

Identifiers

PMID34239862
PMCPMC8258115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.