Evidence map›Paper›PMID 34239698›Full record

ReviewWorld journal of hepatology2021

Glutathione-S-transferases genes-promising predictors of hepatic dysfunction.

Vasyl Prysyazhnyuk, Larysa Sydorchuk, Ruslan Sydorchuk, Iryna Prysiazhniuk, Kateryna Bobkovych, Inna Buzdugan, Valentina Dzuryak, Petro Prysyazhnyuk

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

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  13. Are changes in olanzapine-induced liver enzyme levels associated withArhiv za higijenu rada i toksikologiju · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vasyl PrysyazhnyukDepartment of Propedeutics of Internal Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine. prysyaznyuk_v@ukr.net.
Larysa SydorchukDepartment of Family Medicine, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Ruslan SydorchukDepartment of Surgery, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Iryna PrysiazhniukDepartment of Internal Medicine and Invectious Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Kateryna BobkovychDepartment of Propedeutics of Internal Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Inna BuzduganDepartment of Internal Medicine and Invectious Diseases, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Valentina DzuryakDepartment of Family Medicine, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Petro PrysyazhnyukDepartment of Medical and Pharmaceutical Chemistry, Bukovinian State Medical University, Chernivtsi 58002, Chernivtsi region, Ukraine.
Bukovinian State Medical University · UA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the most commonly known genes involved in chronic diffuse liver diseases pathogenesis are genes that encodes the synthesis of glutathione-S-transferase (GST), known as the second phase enzyme detoxification system that protects against endogenous oxidative stress and exogenous toxins, through catalisation of glutathione sulfuric groups conjugation and decontamination of lipid and deoxyribonucleic acid oxidation products. The group of GST enzymes consists of cytosolic, mitochondrial and microsomal fractions. Recently, eight classes of soluble cytoplasmic isoforms of GST enzymes are widely known: α-, ζ-, θ-, κ-, μ-, π-, σ-, and ω-. The

Indexed as

Drug induced liver diseaseGlutathione-S-transferaseLiver cirrhosisNon-alcoholic fatty liver disease

Identifiers

PMID34239698
PMCPMC8239493
OpenAlexW3176365906

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.