ArticleFrontiers in human neuroscience2021
Fractional Anisotropy in Selected, Motor-Related White Matter Tracts and Its Cross-Sectional and Longitudinal Associations With Motor Function in Healthy Older Adults.
Article in Frontiers in human neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 8 citations in OpenAlex.
- Surgery versus Botulinum Toxin A for Treatment of Post-Stroke Upper-Limb Spasticity: White Matter Changes, Function, and Quality-of-Life-A Randomized Controlled Trial.Neural plasticity · 2026Trial
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Neuroimage. Reports · 2026Article
- Anterior Superior Longitudinal Fasciculus Microstructure Correlates With Bimanual Visuomotor Performance in Healthy Younger but Not Older Adults.The European journal of neuroscience · 2026Article
- Behavioral markers of motor reserve: stability, lateralization, and consistency.Frontiers in aging neuroscience · 2026Article
- Age-group differences in diffusion MRI characteristics of cortico-cerebellar tracts and their association with bimanual performance.Frontiers in aging neuroscience · 2026Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- Volumetric regional MRI and neuropsychological predictors of motor task variability in cognitively unimpaired, Mild Cognitive Impairment, and probable Alzheimer's disease older adults.Experimental gerontology · 2023Article
- Identification of individual subjects based on neuroanatomical measures obtained 7 years earlier.The European journal of neuroscience · 2022Article
- Article
- Cortical Thickness Predictors of Performance-Based Functional Task Variability in the Alzheimer Disease Spectrum.Alzheimer disease and associated disordersArticle
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile it is well-known that deficits in motor performance and brain structural connectivity occur in the course of healthy aging, it is still unclear if and how these changes are related to each other. While some cross-sectional studies suggest that white matter (WM) microstructure is positively associated with motor function in healthy older adults, more evidence is needed. Moreover, longitudinal data is required to estimate whether similar associations can be found between trajectories of change in WM microstructure and motor function. The current study addresses this gap by investigating age-associations and longitudinal changes in WM microstructure and motor function, and the cross-sectional (level-level) and longitudinal (level-change, change-change) association between these two domains.
methodWe used multiple-occasion data (covering 4 years) from a large sample (
resultsThe results revealed longitudinal decline and negative cross-sectional age-associations for mean WM FA in the FMIN and SLF, and for motor function in all tests, with a higher vulnerability for left than right hand motor performance. Regarding cross-domain associations, we found a significant positive level-level correlation among mean WM FA in the FMIN with motor speed. Mean FA in SLF and CST was not correlated with motor performance measures, and none of the level-change or change-change associations were significant. Overall, our results (a) provide important insights into aging-related changes of fine motor abilities and FA in selected white matter tracts associated with motor control, (b) support previous cross-sectional work showing that neural control of movement in older adults also involves brain structures outside the core motor system and (c) align with the idea that, in healthy aging, compensatory mechanisms may be in place and longer time delays may be needed to reveal level-change or change-change associations.
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