Evidence map›Paper›PMID 34239411›Full record

ArticleFrontiers in neuroscience2021

Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine.

Charlotte K Bainomugisa, Heidi G Sutherland, Richard Parker, Allan F Mcrae, Larisa M Haupt, Lyn R Griffiths, Andrew Heath, Elliot C Nelson, Margaret J Wright, Ian B Hickie and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Article
  9. The Epigenetics of Migraine.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. An Axis between the Long Non-Coding RNAInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Charlotte K BainomugisaCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Heidi G SutherlandCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Richard ParkerQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD, Australia.
Allan F McraeInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
Larisa M HauptCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Lyn R GriffithsCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Andrew HeathDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, United States.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, United States.
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Ian B HickieBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Herston, QLD, Australia.
Dale R NyholtCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Divya MehtaCentre for Genomics and Personalised Health, School of Biomedical Science, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Queensland University of Technology · AUQIMR Berghofer Medical Research Institute · AUUniversity of Queensland · AUWashington University in St. Louis · USUniversity of Sydney · AU

Funding

PILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI SHER, KENNETH JAMES · 1999 to 2008
$12.6M
Molecular Epidemiology of Alcoholism 3 - EDAC FamiliesR01AA013321 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2001 to 2005
$4.3M
Genetic Epideniologic Models of Alcohol AbuseR37AA007728 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1998 to 2007
$2.2M
Childhood Trauma, Parental Alcoholism,and ComorbidityR01AA013446 · NIAAA · WASHINGTON UNIVERSITY · PI NELSON, ELLIOT C · 2002 to 2006
$2.2M
Molecular Epidemiology of Alcoholism 1: Candidate GeneR01AA013326 · NIAAA · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI MARTIN, NICHOLAS G · 2001 to 2005
$2.1M
PERSISTENCE AND CHANGE IN DRINKING HABITS--PROJECT TWOR01AA010249 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1995 to 1998
–
NATURAL HISTORY OF ALCOHOL USE &ABUSE--GENETIC MODELSR01AA007728 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1988 to 1998
–
NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA010249NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA013446NIAAA NIH HHS R37 AA007728
6 · The paper itself

Abstract

Epigenetic mechanisms have been associated with genes involved in Posttraumatic stress disorder (PTSD). PTSD often co-occurs with other health conditions such as depression, cardiovascular disorder and respiratory illnesses. PTSD and migraine have previously been reported to be symptomatically positively correlated with each other, but little is known about the genes involved. The aim of this study was to understand the comorbidity between PTSD and migraine using a monozygotic twin disease discordant study design in six pairs of monozygotic twins discordant for PTSD and 15 pairs of monozygotic twins discordant for migraine. DNA from peripheral blood was run on Illumina EPIC arrays and analyzed. Multiple testing correction was performed using the Bonferroni method and 10% false discovery rate (FDR). We validated 11 candidate genes previously associated with PTSD including

Indexed as

DNA methylationgenesmigraineposttraumatic stress disordertwins

Identifiers

PMID34239411
PMCPMC8258453
OpenAlexW3176384169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.