Evidence map›Paper›PMID 34239262›Full record

ReviewWorld journal of gastroenterology2021

Chronic intestinal failure and short bowel syndrome in Crohn's disease.

Aysegül Aksan, Karima Farrag, Irina Blumenstein, Oliver Schröder, Axel U Dignass, Jürgen Stein

Open access · bronzeAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Surgical reconstruction in a 100-year-old patient with short bowel syndrome under palliative care: A case report.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Crohn's disease exacerbated by ghost pills of upadacitinib.Clinical journal of gastroenterology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. [Practical guideline for short bowel syndrome].Zeitschrift fur Gastroenterologie · 2025
    Review
  17. Article
  18. Nutrients · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aysegül AksanInstitute of Nutritional Sciences, Justus-Liebig-Universität, Giessen 35392, Germany.
Karima FarragDepartment of Clinical Research, Interdisziplinäres Crohn Colitis Centrum Rhein-Main, Frankfurt am Main 60594, Germany.
Irina BlumensteinDepartment of Gastroenterology, Hepatology and Clinical Nutrition, First Medical Clinic, JW Goethe University Hospital, Frankfurt am Main 60529, Germany.
Oliver SchröderDepartment of Clinical Research, Interdisziplinäres Crohn Colitis Centrum Rhein-Main, Frankfurt am Main 60594, Germany.
Axel U DignassDepartment of Medicine I, Agaplesion Markus Hospital, Goethe-University, Frankfurt am Main 60431, Germany.
Jürgen SteinDepartment of Clinical Research, Interdisziplinäres Crohn Colitis Centrum Rhein-Main, Frankfurt am Main 60594, Germany.
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic intestinal failure (CIF) is a rare but feared complication of Crohn's disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide spectrum of symptoms, from single micronutrient malabsorption to complete intestinal failure. Management of CIF has improved significantly in recent years. Advances in home-based parenteral nutrition, in particular, have translated into increased survival and improved quality of life. Nevertheless, 60% of patients are permanently reliant on parenteral nutrition. Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy. The outcomes of patients with CIF could be greatly improved by more effective prevention, understanding, and treatment. In complex cases, the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation, nutritional support, and an improved quality of life. Here, we summarize current literature on CIF and short bowel syndrome, encompassing epidemiology, pathophysiology, and advances in surgical and medical management, and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.

Indexed as

Crohn DiseaseIntestinal DiseasesParenteral Nutrition, HomeShort Bowel SyndromeChronic DiseaseHumansQuality of LifeChronic intestinal failureCrohn's diseaseInflammatory bowel diseaseIntestinal failure-associated liver diseaseParenteral nutritionShort bowel syndrome

Identifiers

PMID34239262
PMCPMC8240052
OpenAlexW3173501694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.