ArticleCell research2021
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G
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Article in Cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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What it found
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Who cites it
25 citing papers in PubMed.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Direct β-arrestin engagement by the non-canonical WNT receptor FZD6 via a shallow binding pocket.Acta pharmacologica Sinica · 2026Article
- Targeting frizzled receptors (FZDs) for anti-tumor therapy: From orthosteric to allosteric inhibition.Acta pharmaceutica Sinica. B · 2026Review
- Targeting frizzleds with small-molecule compounds-back to square one or light at the end of the tunnel?The Journal of biological chemistry · 2026Review
- Beyond Small Molecules: Orchestrating Cell Fate with Engineered Water-Soluble Membrane Proteins.Biomolecules · 2026Article
- In silico docking yields small molecule negative allosteric modulators targeting the core of Frizzled 7.Nature communications · 2025Article
- Frizzled receptors: gatekeepers of Wnt signaling in development and disease.Frontiers in cell and developmental biology · 2025Review
- A Putative Frizzled 7-Targeting Compound Acts as a Firefly Luciferase Inhibitor.Journal of medicinal chemistry · 2024Article
- Challenging Reported Frizzled-Targeting Compounds in Selective Assays Reveals Lack of Functional Inhibition and Claimed Profiles.ACS pharmacology & translational science · 2024Article
- Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation.Nature communications · 2024Article
- Structural basis of frizzled 7 activation and allosteric regulation.Nature communications · 2024Article
- Structural insights into Frizzled3 through nanobody modulators.Nature communications · 2024Article
- Absence of calcium-sensing receptor basal activity due to inter-subunit disulfide bridges.Communications biology · 2024Article
- Constitutive activation mechanism of a class C GPCR.Nature structural & molecular biology · 2024Article
- Heterotrimeric G protein signaling without GPCRs: The Gα-binding-and-activating (GBA) motif.The Journal of biological chemistry · 2024Review
- A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways.Cell discovery · 2024Article
- Structure, function and drug discovery of GPCR signaling.Molecular biomedicine · 2023Review
- Pathway selectivity in Frizzleds is achieved by conserved micro-switches defining pathway-determining, active conformations.Nature communications · 2023Article
- G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.Signal transduction and targeted therapy · 2023Review
- Activation mechanism of the human Smoothened receptor.Biophysical journal · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Lu Xu *iHuman Institute, ShanghaiTech University, Shanghai, China.
Bo Chen *iHuman Institute, ShanghaiTech University, Shanghai, China.
Hannes Schihada *Section of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1889-1636
Shane C Wright *Section of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7470-5068
Ainoleena TurkuSection of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Yiran WuiHuman Institute, ShanghaiTech University, Shanghai, China.ORCID http://orcid.org/0000-0001-6790-7473
Gye-Won HanDepartments of Biological Sciences and Chemistry, Bridge Institute, University of Southern California, Los Angeles, CA, USA.
Maria Kowalski-JahnSection of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Pawel KozielewiczSection of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1414-3566
Carl-Fredrik BowinSection of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-9090-9493
Xianjun ZhangiHuman Institute, ShanghaiTech University, Shanghai, China.
Chao LiiHuman Institute, ShanghaiTech University, Shanghai, China.
Michel BouvierInstitute for Research in Immunology and Cancer, Department of Biochemistry and Molecular Medicine, Université de Montréal, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-1128-0100
Gunnar SchulteSection of Receptor Biology & Signaling, Department of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden. gunnar.schulte@ki.se.ORCID http://orcid.org/0000-0002-2700-7013
Fei XuiHuman Institute, ShanghaiTech University, Shanghai, China. xufei@shanghaitech.edu.cn.ORCID http://orcid.org/0000-0003-0719-3901
Funding
CIHR FDN-148431National Natural Science Foundation of China (National Science Foundation of China) 32071194Svenska Sällskapet för Medicinsk Forskning (Swedish Society for Medical Research) P18-0098
Abstract
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Indexed as
Cryoelectron MicroscopyHumansModels, MolecularProtein Conformation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.