Evidence map›Paper›PMID 34238993›Full record

ArticleScientific reports2021

Identification of V6.51L as a selectivity hotspot in stereoselective A

Xuesong Wang, Willem Jespers, Rubén Prieto-Díaz, Maria Majellaro, Adriaan P IJzerman, Gerard J P van Westen, Eddy Sotelo, Laura H Heitman, Hugo Gutiérrez-de-Terán

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuesong Wang *Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Willem Jespers *Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Rubén Prieto-Díaz *Centro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain.
Maria MajellaroCentro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain.
Adriaan P IJzermanDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Gerard J P van WestenDivision of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.
Eddy SoteloCentro Singular de Investigación en Química Biolóxica Y Materiais Moleculares (CIQUS), Santiago de Compostela, Spain. e.sotelo@usc.es.
Laura H HeitmanDepartment of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Box 596, 751 24, Biomedical CenterUppsala, Sweden. l.h.heitman@lacdr.leidenuniv.nl.
Hugo Gutiérrez-de-TeránDepartment of Cell and Molecular Biology and Science for Life Laboratory, Uppsala University, Box 596, 751 24, Biomedical CenterUppsala, Sweden. hugo.gutierrez@icm.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The four adenosine receptors (ARs) A

Indexed as

Amino Acid SubstitutionAmino Acid SequenceChromatography, High Pressure LiquidHEK293 CellsHumansLigandsModels, MolecularPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2AReceptor, Adenosine A2BStereoisomerismThermodynamicsLigandsPurinergic P1 Receptor AntagonistsReceptor, Adenosine A2AReceptor, Adenosine A2B

Identifiers

PMID34238993
PMCPMC8266863

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.