Evidence map›Paper›PMID 34238978›Full record

ArticleScientific reports2021

Quantifying superspreading for COVID-19 using Poisson mixture distributions.

Cécile Kremer, Andrea Torneri, Sien Boesmans, Hanne Meuwissen, Selina Verdonschot, Koen Vanden Driessche, Christian L Althaus, Christel Faes, Niel Hens

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
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  18. The role of super-spreaders in modeling of SARS-CoV-2.Infectious Disease Modelling · 2022
    Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Cécile Kremer *Interuniversity Institute for Biostatistics and statistical Bioinformatics, Data Science Institute, Hasselt University, Hasselt, Belgium. cecile.kremer@uhasselt.be.
Andrea Torneri *Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Sien BoesmansFaculty of Sciences, Hasselt University, Hasselt, Belgium.
Hanne MeuwissenFaculty of Sciences, Hasselt University, Hasselt, Belgium.
Selina VerdonschotFaculty of Sciences, Hasselt University, Hasselt, Belgium.
Koen Vanden DriesscheDivision of Pulmonology, Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium.
Christian L AlthausInstitute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Christel FaesInteruniversity Institute for Biostatistics and statistical Bioinformatics, Data Science Institute, Hasselt University, Hasselt, Belgium.
Niel HensInteruniversity Institute for Biostatistics and statistical Bioinformatics, Data Science Institute, Hasselt University, Hasselt, Belgium.
Hasselt University · BEUniversity of Antwerp · BEAntwerp University Hospital · BEUniversity of Bern · CH

Funding

European Research Council grant agreement 682540 - TransMIDEuropean Union's Horizon 2020 research and innovation programme - project EpiPose grant agreement number 101003688
6 · The paper itself

Abstract

The number of secondary cases, i.e. the number of new infections generated by an infectious individual, is an important parameter for the control of infectious diseases. When individual variation in disease transmission is present, like for COVID-19, the distribution of the number of secondary cases is skewed and often modeled using a negative binomial distribution. However, this may not always be the best distribution to describe the underlying transmission process. We propose the use of three other offspring distributions to quantify heterogeneity in transmission, and we assess the possible bias in estimates of the mean and variance of this distribution when the data generating distribution is different from the one used for inference. We also analyze COVID-19 data from Hong Kong, India, and Rwanda, and quantify the proportion of cases responsible for 80% of transmission, [Formula: see text], while acknowledging the variation arising from the assumed offspring distribution. In a simulation study, we find that variance estimates may be biased when there is a substantial amount of heterogeneity, and that selection of the most accurate distribution from a set of distributions is important. In addition we find that the number of secondary cases for two of the three COVID-19 datasets is better described by a Poisson-lognormal distribution.

Indexed as

SARS-CoV-2Computer SimulationCOVID-19Hong KongHumansIndiaInfectious Disease Transmission, VerticalPoisson DistributionRwanda

Identifiers

PMID34238978
PMCPMC8266910
OpenAlexW3181358231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.