Evidence map›Paper›PMID 34238964›Full record

ArticleScientific reports2021

Occurrence of mcr-mediated colistin resistance in Salmonella clinical isolates in Thailand.

Sirirat Luk-In, Tanittha Chatsuwan, Naris Kueakulpattana, Ubolrat Rirerm, Dhammika Leshan Wannigama, Rongpong Plongla, Ratana Lawung, Chaiwat Pulsrikarn, Siriporn Chantaroj, Pattharaporn Chaichana and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Widespread antibiotic-resistantOne health (Amsterdam, Netherlands) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. African health sciences · 2025
    Article
  9. Antibiotic and colistin resistance pattern ofNew microbes and new infections · 2025
    Article
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Sirirat Luk-InDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Tanittha ChatsuwanDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Tanittha.C@chula.ac.th.
Naris KueakulpattanaDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ubolrat RirermDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Dhammika Leshan WannigamaDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Rongpong PlonglaAntimicrobial Resistance and Stewardship Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Ratana LawungDepartment of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom, Thailand.
Chaiwat PulsrikarnSalmonella and Shigella Center, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Siriporn ChantarojSalmonella and Shigella Center, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Pattharaporn ChaichanaDepartment of Medical Sciences, Medical Science Center Khon Kaen, Nonthaburi, Thailand.
Nattida SaksaengsopaSalmonella and Shigella Center, National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand.
Teerarat ShanthacholQueen Savang Vadhana Memorial Hospital, Thai Red Cross Society, Chonburi, Thailand.
Malee TechapornroongDepartment of Medicine, Prapokklao Hospital, Chanthaburi, Thailand.
Sunee ChayangsuDepartment of Internal Medicine, Surin Hospital, Surin, Thailand.
Wanla KulwichitDepartment of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Chulalongkorn University · THDepartment of Medical Sciences · THNational Institute of Health of Thailand · THThai Red Cross Society · THMahidol University · THPrapokklao Hospital · THSurin Hospital · THUniversity of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nontyphoidal Salmonella, an important zoonotic pathogen and a major cause of foodborne illnesses, could be a potential reservoir of plasmids harbouring mobile colistin resistance gene (mcr). This study reported, for the first time, a high rate of mcr-carrying Salmonella clinical isolates (3.3%, 24/724) in Thailand, associated with mcr-3 gene (3.0%, 22/724) in S. 4,[5],12:i:-(15.4%, 4/26), S. Typhimurium (8.8%, 5/57), and S. Choleraesuis (5.6%, 13/231). Remarkably, the increasing trends of colistin and extended-spectrum cephalosporin resistances have displayed a high agreement over the years, with a dramatic rise in the mcr-carrying Salmonella from 1.1% (6/563) during 2005-2007 to 11.2% (18/161) during 2014-2018 when CTX-M-55 became abundant. Clonal and plasmid analysis revealed that the self-transferable IncA/C and a novel hybrid IncA/C-FIIs MDR plasmids were the major vehicles to disseminate both mcr-3 and bla

Indexed as

Genes, BacterialColistinDrug Resistance, BacterialHumansMicrobial Sensitivity TestsPhylogenyPlasmidsSalmonellaThailandColistin

Identifiers

PMID34238964
PMCPMC8266838
OpenAlexW3178481396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.