Evidence map›Paper›PMID 34238765›Full record

ArticleMolecules and cells2021

cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy.

So-Yoon Won, Soon-Tae You, Seung-Won Choi, Catriona McLean, Eun-Young Shin, Eung-Gook Kim

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. TheMolecules and cells · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

So-Yoon WonDepartment of Biological Sciences, Konkuk University, Seoul 05029, Korea.ORCID https://orcid.org/0000-0002-7582-2549
Soon-Tae YouDepartment of Neurosurgery, The Catholic University of Korea, St. Vincent's Hospital, Suwon 16247, Korea.ORCID https://orcid.org/0000-0002-0681-1774
Seung-Won ChoiDaegu Gyeongbuk Institute of Science & Technology, Daegu 42988, Korea.ORCID https://orcid.org/0000-0001-8610-887X
Catriona McLeanDepartment of Pathology, The Alfred Hospital, Melbourne 3004, Australia.ORCID https://orcid.org/0000-0002-0302-5727
Eun-Young ShinDepartment of Biochemistry, Chungbuk National University College of Medicine, Cheongju 28644, Korea.ORCID https://orcid.org/0000-0002-9527-4535
Eung-Gook KimDepartment of Biochemistry, Chungbuk National University College of Medicine, Cheongju 28644, Korea.ORCID https://orcid.org/0000-0001-8232-5666
Chungbuk National University · KRDaegu Gyeongbuk Institute of Science and Technology · KRKonkuk University · KRThe Alfred Hospital · AUThe Catholic University of Korea St. Vincent's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by a progressive loss of dopamine-producing neurons in the midbrain, which results in decreased dopamine levels accompanied by movement symptoms. Oral administration of l-3,4-dihydroxyphenylalanine (L-dopa), the precursor of dopamine, provides initial symptomatic relief, but abnormal involuntary movements develop later. A deeper understanding of the regulatory mechanisms underlying dopamine homeostasis is thus critically needed for the development of a successful treatment. Here, we show that p21-activated kinase 4 (PAK4) controls dopamine levels. Constitutively active PAK4 (caPAK4) stimulated transcription of tyrosine hydroxylase (TH) via the cAMP response element-binding protein (CREB) transcription factor. Moreover, caPAK4 increased the catalytic activity of TH through its phosphorylation of S

Indexed as

AnimalsCyclic AMP Response Element-Binding ProteinDopamineHumansp21-Activated KinasesPhosphorylationRatsTransfectionTyrosine 3-MonooxygenaseCyclic AMP Response Element-Binding ProteinDopaminep21-Activated KinasesPAK4 protein, humanTyrosine 3-MonooxygenasedopaminePAK4Parkinson's diseasePost treat­mentTyrosine hydroxylase

Identifiers

PMID34238765
PMCPMC8334344
OpenAlexW3181767932

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.