Evidence map›Paper›PMID 34238764›Full record

ArticleAging2021

A model of the aged lung epithelium in idiopathic pulmonary fibrosis.

Hoora Shaghaghi, Karina Cuevas-Mora, Rachel Para, Cara Tran, Willy Roque, Matthew J Robertson, Ivan O Rosas, Ross Summer, Freddy Romero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Altered Metabolism in Idiopathic Pulmonary Fibrosis.Journal of cellular physiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. CD38 Mediates Lung Fibrosis by Promoting Alveolar Epithelial Cell Aging.American journal of respiratory and critical care medicine · 2022
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hoora ShaghaghiDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane and Leonard Korman Respiratory Institute, Philadelphia, PA 19107, USA.
Karina Cuevas-MoraDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane and Leonard Korman Respiratory Institute, Philadelphia, PA 19107, USA.
Rachel ParaDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane and Leonard Korman Respiratory Institute, Philadelphia, PA 19107, USA.
Cara TranDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane and Leonard Korman Respiratory Institute, Philadelphia, PA 19107, USA.
Willy RoqueDepartment of Medicine, Rutgers - New Jersey Medical School, Newark, NJ 07103, USA.
Matthew J RobertsonPulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Ivan O RosasPulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Ross SummerDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care and the Center for Translational Medicine, The Jane and Leonard Korman Respiratory Institute, Philadelphia, PA 19107, USA.
Freddy RomeroPulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · USRutgers New Jersey Medical School

Funding

Metabolic control of DNA repair in pulmonary fibrosisR01HL131784 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI SUMMER, ROSS S · 2017 to 2020
$1.6M
PROTEASOME DEGRADATION OF P53 DRIVES HPS LUNG FIBROSISR01HL136833 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ROMERO, FREDDY · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL131784NHLBI NIH HHS R01 HL136833
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is an age-related disorder that carries a universally poor prognosis and is thought to arise from repetitive micro injuries to the alveolar epithelium. To date, a major factor limiting our understanding of IPF is a deficiency of disease models, particularly

Indexed as

AnimalsAntibiotics, AntineoplasticBleomycinCell LineCellular SenescenceDisease Models, AnimalEnergy MetabolismHomeostasisHumansIdiopathic Pulmonary FibrosisLungMiceMitochondriaOxidation-ReductionProteasome Endopeptidase ComplexProteinsAntibiotics, AntineoplasticBleomycinProteasome Endopeptidase ComplexProteinsagingepithelial cellsIPFmitochondriaproteostasis

Identifiers

PMID34238764
PMCPMC8312437
OpenAlexW3177971333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.