Evidence map›Paper›PMID 34238546›Full record

Trial reportBritish journal of anaesthesia2021

Proteomic signatures for perioperative oxygen delivery in skin after major elective surgery: mechanistic sub-study of a randomised controlled trial.

Wendy E Heywood, Emily Bliss, Fatima Bahelil, Trinda Cyrus, Marilena Crescente, Timothy Jones, Sadaf Iqbal, Laura G Paredes, Andrew J Toner, Ana G Del Arroyo and 3 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Wendy E HeywoodTranslational Mass Spectrometry Research Group, UCL Institute of Child Health, London, UK.
Emily BlissTranslational Mass Spectrometry Research Group, UCL Institute of Child Health, London, UK.
Fatima BahelilTranslational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Trinda CyrusTranslational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Marilena CrescenteDepartment of Life Sciences, Manchester Metropolitan University Manchester, UK.
Timothy JonesTranslational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Sadaf IqbalUniversity College London NHS Hospitals Trust, London, UK.
Laura G ParedesUniversity College London NHS Hospitals Trust, London, UK.
Andrew J TonerDepartment of Anesthesia, Royal Perth Hospital, Perth, Western Australia, Australia.
Ana G Del ArroyoTranslational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
Edel A O'TooleCentre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.
Kevin MillsTranslational Mass Spectrometry Research Group, UCL Institute of Child Health, London, UK.
Gareth L AcklandTranslational Medicine & Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK. Electronic address: g.ackland@qmul.ac.uk.
Queen Mary University of London · GBUniversity College London · GBUniversity College London Hospitals NHS Foundation Trust · GBManchester Metropolitan University · GBRoyal Perth Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaintaining adequate oxygen delivery (DO

methodsParticipants undergoing elective oesophagectomy were randomised immediately after surgery to standard of care or haemodynamic therapy to achieve their individualised preoperative DO

resultsPaired punch skin biopsies were obtained from 35 participants (mean age: 68 yr; 31% female), of whom 17 underwent oesophagectomy. There were 14/2096 proteins associated with normal (n=10) vs low (n=7) DO

conclusionsProteomic profiles in serial skin biopsies identified organ-protective mechanisms associated with normal DO CLINICAL

trial registrationISRCTN76894700.

Indexed as

ProteomicsAgedAged, 80 and overBiopsyDouble-Blind MethodElective Surgical ProceduresEsophagectomyFemaleHumansMaleMiddle AgedOxygenPerioperative CareProteinsSkinOxygenProteinsoxygen deliveryproteomicsrandomised controlled trialsepsisskinsurgerywound infection

Identifiers

PMID34238546
PMCPMC8524389
OpenAlexW3181269497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.