ArticleBMC genomics2021
Amino acid transporter (AAT) gene family in foxtail millet (Setaria italica L.): widespread family expansion, functional differentiation, roles in quality formation and response to abiotic stresses.
Article in BMC genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 35 citations in OpenAlex.
- Investigating the functions of glycosyl hydrolase family 1 in foxtail millet through an integrated genome-wide survey, expression profiling, and variation analysis.BMC plant biology · 2026Article
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- Comparative transcriptome analysis revealed that tomato response to salt stress induced by exogenous GABA and functional verification of SlGAD1.BMC plant biology · 2025Article
- Rapid and Non-Destructive Assessment of Eight Essential Amino Acids in Foxtail Millet: Development of an Efficient and Accurate Detection Model Based on Near-Infrared Hyperspectral.Foods (Basel, Switzerland) · 2025Article
- Genome-wide identification of the AAT gene family in quinoa and analysis of its expression pattern under abiotic stresses.BMC genomics · 2025Article
- Genome-wide identification of the AAAP gene family and expression analysis under tissue-specific expression in five legumes.BMC genomics · 2025Article
- Bioinformatics and Expression Analyses of theInternational journal of molecular sciences · 2024Article
- High Overexpression ofInternational journal of molecular sciences · 2024Article
- Genome-wide identification and comparative analysis of the Amino Acid Transporter (AAT) gene family and their roles during Phaseolus vulgaris symbioses.Functional & integrative genomics · 2024Article
- An integration of genome-wide survey, homologous comparison and gene expression analysis provides a basic framework for the ZRT, IRT-like protein (ZIP) in foxtail millet.Frontiers in plant science · 2024Article
- Genome-wide identification and expression analysis of the U-box E3 ubiquitin ligase gene family related to bacterial wilt resistance in tobacco (Frontiers in plant science · 2024Article
- Identification and expression of theFrontiers in genetics · 2024Article
- Genome-Wide Identification and Functional Analysis of Lysine Histidine Transporter (LHT) Gene Families in Maize.Genetics research · 2022Article
- Multi-omics intervention inFrontiers in plant science · 2022Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAmino acid transporters (AATs) plays an essential roles in growth and development of plants, including amino acids long-range transport, seed germination, quality formation, responsiveness to pathogenic bacteria and abiotic stress by modulating the transmembrane transfer of amino acids. In this study, we performed a genome-wide screening to analyze the AAT genes in foxtail millet (Setaria italica L.), especially those associated with quality formation and abiotic stresses response.
resultsA total number of 94 AAT genes were identified and divided into 12 subfamilies by their sequence characteristics and phylogenetic relationship. A large number (58/94, 62%) of AAT genes in foxtail millet were expanded via gene duplication, involving 13 tandem and 12 segmental duplication events. Tandemly duplicated genes had a significant impact on their functional differentiation via sequence variation, structural variation and expression variation. Further comparison in multiple species showed that in addition to paralogous genes, the expression variations of the orthologous AAT genes also contributed to their functional differentiation. The transcriptomic comparison of two millet cultivars verified the direct contribution of the AAT genes such as SiAAP1, SiAAP8, and SiAUX2 in the formation of grain quality. In addition, the qRT-PCR analysis suggested that several AAT genes continuously responded to diverse abiotic stresses, such as SiATLb1, SiANT1. Finally, combined with the previous studies and analysis on sequence characteristics and expression patterns of AAT genes, the possible functions of the foxtail millet AAT genes were predicted.
conclusionThis study for the first time reported the evolutionary features, functional differentiation, roles in the quality formation and response to abiotic stresses of foxtail millet AAT gene family, thus providing a framework for further functional analysis of SiAAT genes, and also contributing to the applications of AAT genes in improving the quality and resistance to abiotic stresses of foxtail millet, and other cereal crops.
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