Evidence map›Paper›PMID 34238018›Full record

ArticleJournal of the American Heart Association2021

Factors Associated With Health-Related Quality of Life 2 Years After Left Ventricular Assist Device Implantation: Insights From INTERMACS.

Kathleen L Grady, Pariya L Fazeli, James K Kirklin, Salpy V Pamboukian, Connie White-Williams

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07445932 (The PALL-VAD Study), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07445932 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The PALL-VAD Study: Palliative Care Intervention to Improve Health Related Quality of Life for Patients With Heart Failure on Long-Term LVAD Support: A Pilot, Prospective, Randomized Trial

TypeinterventionalSponsorMedstar Health Research InstituteRan2026 to 2027Enrolled90ConditionsAdvanced Heart Failure, Mechanical Circulatory Support, Left Ventricular Assist Device, Palliative CareArmsPalliative care intervention
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Efficient measurement of multiple ventricular assist device patient-reported outcomes: Creation of a 20-item profile from the MCS A-QOL study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  7. Novel measures to assess ventricular assist device patient-reported outcomes: Findings from the MCS A-QOL study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kathleen L GradyDepartment of Surgery Northwestern University Chicago IL.
Pariya L FazeliDepartment of Family, Community, and Health Systems University of Alabama at Birmingham School of Nursing Birmingham AL.
James K KirklinDepartment of Surgery University of Alabama at Birmingham Birmingham AL.
Salpy V PamboukianDepartment of Surgery University of Alabama at Birmingham Birmingham AL.
Connie White-WilliamsUniversity of Alabama at Birmingham Hospital Birmingham AL.
University of Alabama at Birmingham · USNorthwestern University · USUniversity of Alabama at Birmingham Hospital · US

Funding

NHLBI NIH HHS HHSN268201100025C
6 · The paper itself

Abstract

Background Factors related to health-related quality of life (HRQOL) 2 years after left ventricular assist device (LVAD) implantation are unknown. We sought to determine whether preimplant intended goal of LVAD therapy (heart transplant candidate [short-term group], uncertain heart transplant candidate [uncertain group], and heart transplant ineligible [long-term group]) and other variables were related to HRQOL 2 years after LVAD implantation. Methods and Results Our LVAD sample (n=1620) was from INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). Using the EuroQol-5 Dimension Questionnaire (EQ-5D-3L), a generic HRQOL measure, and the Kansas City Cardiomyopathy Questionnaire (KCCQ-12), a heart failure-specific HRQOL measure, multivariable linear regression modeling was conducted with the EQ-5D-3L Visual Analog Scale (VAS) score and KCCQ-12 overall summary score (OSS) as separate dependent variables. Two years after LVAD implant, the short-term group had a significantly higher mean VAS score versus the uncertain and long-term groups (short-term: 75.18 [SD, 20.62]; uncertain: 72.27 [SD, 20.33]; long-term: 70.87 [SD, 22.09],

Indexed as

Health StatusQuality of LifeRegistriesAgedFemaleFollow-Up StudiesHeart-Assist DevicesHeart FailureHeart VentriclesHumansMaleRetrospective StudiesTime FactorsTreatment Outcomeheart failureleft ventricular assist devicequality of life

Identifiers

PMID34238018
PMCPMC8483481
OpenAlexW3178898643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.