Evidence map›Paper›PMID 34238012›Full record

ArticleJournal of the American Heart Association2021

Root Dilatation Is More Malignant Than Ascending Aortic Dilation.

Paris D Kalogerakos, Mohammad A Zafar, Yupeng Li, Sandip K Mukherjee, Bulat A Ziganshin, John A Rizzo, John A Elefteriades

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Observational
  11. The natural history of aortic root aneurysms.Annals of cardiothoracic surgery · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Microcalcification and Thoracic Aortopathy: A Window Into Disease Severity.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paris D KalogerakosAortic Institute at Yale-New Haven Hospital Yale University School of Medicine New Haven CT.
Mohammad A ZafarAortic Institute at Yale-New Haven Hospital Yale University School of Medicine New Haven CT.
Yupeng LiDepartment of Political Science and Economics Rowan University Glassboro NJ.
Sandip K MukherjeeAortic Institute at Yale-New Haven Hospital Yale University School of Medicine New Haven CT.
Bulat A ZiganshinAortic Institute at Yale-New Haven Hospital Yale University School of Medicine New Haven CT.
John A RizzoDepartment of Economics and Department of Preventive Medicine Stony Brook University Stony Brook NY.
John A ElefteriadesAortic Institute at Yale-New Haven Hospital Yale University School of Medicine New Haven CT.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Background Data from the International Registry of Acute Aortic Dissection indicate that the guideline criterion of 5.5 cm for ascending aortic intervention misses many dissections occurring at smaller dimensions. Furthermore, studies of natural behavior have generally treated the aortic root and the ascending aorta as 1 unit despite embryological, anatomical, and functional differences. This study aims to disentangle the natural histories of the aforementioned aortic segments, allowing natural behavior to define specific intervention criteria for root and ascending segments of the aorta. Methods and Results Diameters of the aortic root and mid-ascending segment were measured separately. Long-term complications (dissection, rupture, and death) were analyzed retrospectively for 1162 patients with ascending thoracic aortic aneurysm. Cox regression analysis suggested that aortic root dilatation (

Indexed as

AgedAorta, ThoracicAortic Aneurysm, ThoracicAortic DissectionDilatation, PathologicEchocardiographyFemaleFollow-Up StudiesHumansMaleRetrospective StudiesRisk FactorsTime Factorsaneurysmaortic rootdissectionmid‐ascending aortanatural historysurgical threshold

Identifiers

PMID34238012
PMCPMC8483477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.