Evidence map›Paper›PMID 34237797›Full record

ArticleJournal of internal medicine2022

Adherence to a healthy sleep pattern is associated with lower risks of all-cause, cardiovascular and cancer-specific mortality.

Tao Zhou, Yu Yuan, Qiaochu Xue, Xiang Li, Mengying Wang, Hao Ma, Yoriko Heianza, Lu Qi

Open access · greenAbstract read
In one paragraph

Article in Journal of internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The impact of social determinants of health on mental and behavioral health trajectories of breast cancer survivors: A longitudinal cohort study.European journal of oncology nursing : the official journal of European Oncology Nursing Society · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tao ZhouDepartment of Epidemiology and Biostatistics, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, China.
Yu YuanDepartment of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiaochu XueDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Xiang LiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Mengying WangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Hao MaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0003-3323-982X
Yoriko HeianzaDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Lu QiDepartment of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.ORCID 0000-0002-8041-7791
Tulane University · USHuazhong University of Science and Technology · CN

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Nutrigenetics and Nutrigenomics for Precision Weight-Loss Diet InterventionsR01DK115679 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Lu Qi · 2018 to 2026
$5.3M
Common Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2M
TOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8M
Rare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6M
Genome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421k
Dissecting the impact of forced displacement on Type Two DiabetesR21TW010790 · FIC · LEBANESE AMERICAN UNIVERSITY · PI QI, LU, ZALLOUA, PIERRE · 2018 to 2019
$308k
FIC NIH HHS R21 TW010790Medical Research Council MC_PC_17228Medical Research Council MC_QA137853NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383NIDDK NIH HHS R01 DK115679NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616
6 · The paper itself

Abstract

backgroundIndividual unhealthy sleep behaviours have been associated with increased risks of all-cause mortality and deaths due to cardiovascular disease (CVD) or cancer. The evidence regarding the association of sleep patterns with these risks is limited.

objectiveTo examine the associations of sleep patterns with all-cause, CVD and cancer mortality in a large prospective cohort.

methodsThis prospective cohort study included 283,443 adults from UK Biobank without CVD and cancer at baseline. We created a healthy sleep score and sleep patterns combining five individual sleep behaviours.

resultsDuring a mean (standard deviation) of 8.9 (1.1) years (2.5 million person-years) of follow up, a total of 7936 all-cause deaths, 762 CVD-caused deaths, and 4540 cancer-caused deaths occurred during follow up. One point increase of the healthy sleep score was associated with a 4-11% lower risk of all-cause mortality (Hazard Ratio [HR], 0.94; 95% CI, 0.92-0.96), CVD mortality (HR, 0.89; 95% CI, 0.83-0.95) and cancer mortality (HR, 0.96; 95% CI, 0.93-0.99), with adjustment for age, sex, assessment centres, smoking status, alcohol intake status, socioeconomic status and physical activity. Compared with participants with an unfavourable sleep pattern, those with a favourable sleep pattern had 24-42% lower risks of all-cause and CVD mortality. The association with all-cause mortality tended to be stronger among underweight participants and those with insufficient physical activity.

conclusionsA healthy sleep pattern was associated with lower risks of all-cause mortality and mortality from CVD and cancer. Our findings highlight the importance of improving overall sleep behaviours in lowering mortality.

Indexed as

Cardiovascular DiseasesMortalityNeoplasmsSleep QualityAdultHumansProspective StudiesRisk FactorsSleepUnited KingdomcancerCVDmortalitysleepsleep pattern

Identifiers

PMID34237797
PMCPMC8688171
OpenAlexW3182627821

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.