SynthesisNature2021
Mapping the human genetic architecture of COVID-19.
2 registry-linked trialsOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 575 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
575citing papers in PubMed, 6 pooled it
172.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19
The Middle Norway Corona Study - Individual and Genetic Risk Factors for COVID-19 Infection.
Who cites it
575 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,104 citations in OpenAlex.
- Common and rare variant analyses reveal genetic factors underlying idiopathic pulmonary fibrosis and its shared aetiology with severe COVID-19.EBioMedicine · 2025Pooled it
- Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects.Nature genetics · 2025Pooled it
- Challenges in interpreting Mendelian randomization studies with a disease as the exposure: Using COVID-19 liability studies as an exemplar.European journal of human genetics : EJHG · 2025Pooled it
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- A systematic two-sample and bidirectional MR process highlights a unidirectional genetic causal effect of allergic diseases on COVID-19 infection/severity.Journal of translational medicine · 2024Pooled it
- Circulating miRNA profiles in COVID-19 patients and meta-analysis: implications for disease progression and prognosis.Scientific reports · 2023Pooled it
- Systems genetics analysis reveals immune mediators of coronavirus disease severity in mice.Genetics · 2026Article
- The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa.International journal of immunogenetics · 2026Article
- Association of IFN-γ +874 T/A Polymorphism With COVID-19 Susceptibility, Severity, and Inflammatory Response: A Case-Control Study From Southern Iran.Journal of clinical laboratory analysis · 2026Article
- Trop-1/EpCAM Thr115 is a driver of hyperproliferative cell repair and of severe lung damage in COVID-19.iScience · 2026Article
- Integrated Inflammatory, Thrombo-Inflammatory, Redox and Soluble IFNAR2 Profiling During Hospitalization for COVID-19: An Exploratory Observational Cohort Study.Journal of clinical medicine · 2026Article
- Article
- Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways.Royal Society open science · 2026Article
- SARS-CoV-2 Infection-Induced Alterations in ADAR Editing Patterns Differ Between Patients Who Developed Critical Compared to Non-Critical COVID-19.International journal of molecular sciences · 2026Article
- Association of ABO/Rh Blood Groups and ABO Gene VariantsViruses · 2026Article
- Decoding the shared genetic liability of lower respiratory tract infections via genomic structural equation modeling.BMC pulmonary medicine · 2026Article
- Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Identification and functional characterization of regulatory variants in DPP9 associated with COVID-19 severity.Genome medicine · 2026Article
- Comparison of methods for assessing effects of risk factors on disease progression in Mendelian randomization under index event bias.American journal of human genetics · 2026Article
- Article
515 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author at 20 institutions in 37 countries.
COVID-19 Host Genetics Initiative
University of Liverpool · GBUniversity of Siena · ITUniversity of Liège · BEBroad Institute · USRoslin Institute · GBQueen Mary University of London · GBRoyal Hallamshire Hospital · GBBarts Health NHS Trust · GBWestern General Hospital · GBUniversity of Milan · ITAmsterdam University Medical Centers · NLCalderdale Royal Hospital · GBRoyal Surrey County Hospital · GBGlan Clwyd Hospital · GBHumanitas University · ITRoyal Victoria Infirmary · GBSt Thomas' Hospital · GBGreat Ormond Street Hospital · GBColumbia University · USdeCODE Genetics (Iceland) · IS
Funding
University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MHispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8MHarnessing the power of genetic relatedness for disease gene discoveryR01GM133169 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BELOW, JENNIFER, HUFF, CHAD DANIEL · 2019 to 2022
$2.6MIntegrative approaches for mapping the genetic risk of complex traitsR01HG009120 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PASANIUC, BOGDAN · 2017 to 2021
$2.3MBuilding Interdisciplinary Research Careers in Women's HealthK12AR084232 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AMY S MAJOR, Digna R Velez Edwards · 2023 to 2026
$1.3MA framework enabling the genomic analysis of psychiatric traits across admixed populations.K01MH121659 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI ATKINSON, ELIZABETH GRACE · 2019 to 2022
$719kMeasuring Depression: Using biomarkers to investigate the biology of depressionF31MH124306 · NIMH · VANDERBILT UNIVERSITY · PI SEALOCK, JULIA · 2021 to 2021
$31kMedical Research Council G0701075Medical Research Council G0901254Medical Research Council G1001253Medical Research Council MC_EX_MR/M009203/1Medical Research Council MC_PC_14089Medical Research Council MC_PC_19025Medical Research Council MC_PC_19026Medical Research Council MC_PC_19059Medical Research Council MC_PC_20004Medical Research Council MC_UP_A090_1006Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00007/15Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_12008/1Medical Research Council MC_UU_12014/10Medical Research Council MC_UU_12014/12Medical Research Council MC_UU_12014/8Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L501542/1Medical Research Council MR/M009203/1Medical Research Council MR/N02995X/1Medical Research Council MR/P011705/1Medical Research Council MR/P011705/2Medical Research Council MR/R026408/1Medical Research Council MR/S006753/1Medical Research Council MR/S020039/1Medical Research Council MR/S032304/1NHGRI NIH HHS R01 HG009120NHGRI NIH HHS T32 HG000040NHLBI NIH HHS R01 HL142302NIAMS NIH HHS K12 AR084232NIGMS NIH HHS R01 GM133169NIMH NIH HHS F31 MH124306NIMH NIH HHS K01 MH121659Parkinson's UK G-0907Parkinson's UK G-1307Wellcome Trust 210561/Z/18/Z
Abstract
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19
Indexed as
COVID-19Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHost-Pathogen InteractionsAutoimmunityBody Mass IndexCritical IllnessFemaleGeographic MappingHospitalizationHumansInflammationInformation DisseminationMaleMultifactorial Inheritance
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT04316884ClinicalTrials.gov
NCT05638178ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.