Evidence map›Paper›PMID 34237680›Full record

ArticleClinical neurology and neurosurgery2021

Correlates of deep brain stimulation consensus conference decision to treat primary dystonia.

Lindsay Niccolai, Stephen L Aita, Harrison C Walker, Victor A Del Bene, Adam Gerstenecker, Dario Marotta, Meredith Gammon, Roy C Martin, Olivio J Clay, Michael Crowe and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical neurology and neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Lindsay NiccolaiDepartment of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stephen L AitaDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA; Department of Psychiatry & Behavioral Neurobiology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA; Department of Psychology, University of South Alabama, Mobile, AL, USA.
Harrison C WalkerDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Victor A Del BeneDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Adam GersteneckerDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Dario MarottaDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Meredith GammonDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Roy C MartinDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Olivio J ClayDepartment of Psychology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Michael CroweDepartment of Psychology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Kristen L TriebelDepartment of Neurology, University of Alabama at Birmingham (UAB), Birmingham, AL, USA. Electronic address: ktriebel@uabmc.edu.
University of Alabama at Birmingham · USThe University of Texas MD Anderson Cancer Center · USUniversity of Alabama at Birmingham Hospital · US

Funding

Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinson's DiseaseUH3NS100553 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, HARRISON CARROLL · 2016 to 2021
$7.3M
NINDS NIH HHS UH3 NS100553
6 · The paper itself

Abstract

backgroundDeep brain stimulation (DBS) is an effective treatment for motor disturbance in people with primary dystonia (PWD). Numerous factors are considered by an interdisciplinary consensus conference before deciding candidacy for DBS surgery (e.g., demographic, medical, cognitive, and behavioral factors). However, little is known about which of these factors are associated with PWD DBS surgery consensus conference decisions.

objectiveOur goal was to examine whether pre-operative demographic, medical, and cognitive/behavioral variables are associated DBS consensus conference decisions in patients with dystonia.

methodsThirty-two PWD completed comprehensive presurgery workup included neurological and neuropsychological exams, and neuroimaging in consideration for DBS surgery. An interdisciplinary conference committee either recommended or did not recommend DBS surgery based upon these data. Demographic and medical data (e.g., dystonia disease characteristics, medical comorbidities, medications) were also collected. We also examined impact from cardiovascular disease factors, using a Revised Cardiac Risk Index. PWD were grouped based on DBS conference decision (eligible: n = 21, ineligible: n = 11) and compared across demographic, medical, and cognitive/behavioral variables.

resultsAcross clinical variables, PWD who were deemed ineligible for DBS surgery had a higher Revised Cardiac Risk Index. PWD who were classified as ineligible displayed lower global cognitive functioning, working memory, phonemic fluency, memory retrieval, and cognitive flexibility.

conclusionsConsensus decision making regarding DBS surgery eligibility involves a multifactorial process. We found that deficits in executive functioning were associated with the DBS consensus committee decision. We also observed elevated cardiac risk among these individuals, likely reflecting the relation between vascular health and cognition. Implications, and clinical and scientific applications of these findings are discussed.

Indexed as

ConsensusAdultAgedClinical Decision-MakingDeep Brain StimulationDystonic DisordersFemaleHumansMaleMiddle AgedCognitionDeep brain stimulationMovement disordersNeuropsychologyPrimary dystonia

Identifiers

PMID34237680
PMCPMC8386520
OpenAlexW3167285806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.