Evidence map›Paper›PMID 34237522›Full record

ArticleInternational journal of pediatric otorhinolaryngology2021

Dysphonia and dysphagia consequences of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS).

Rhiannon Halfpenny, Alexandra Stewart, Alison Carter, Michelle Wyatt, Christopher Jephson, Emma O'Dwyer, Lesley Cavalli

Open access · greenAbstract read
In one paragraph

Article in International journal of pediatric otorhinolaryngology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 4 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Post-MIS-C cardiovascular outcomes: a systematic review.European journal of pediatrics · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Short and Long-Term Wellbeing of Children following SARS-CoV-2 Infection: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  5. Article
  6. Review
  7. Post‑COVID‑19 syndrome in children (Review).Experimental and therapeutic medicine · 2022
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rhiannon HalfpennyGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK; University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: Rhiannon.halfpenny@gosh.nhs.uk.
Alexandra StewartGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK; University College London, Gower Street, London, WC1E 6BT, UK.
Alison CarterGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK.
Michelle WyattGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK.
Christopher JephsonGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK.
Emma O'DwyerGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK.
Lesley CavalliGreat Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK; University College London, Gower Street, London, WC1E 6BT, UK.
Great Ormond Street Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importancePaediatric inflammatory multisystem syndrome, temporally associated with SARS-CoV-2 (PIMS-TS) is a novel disease first identified in 2020. Recent cohort studies have described the complex presentation and symptomatology. This paper provides detailed description of the dysphagia and dysphonia symptoms, management, and outcome.

objectiveTo describe dysphagia and dysphonia in PIMS-TS.

designRetrospective cohort study.

settingSingle tertiary and quaternary children's hospital.

participantsAll 50 children treated for paediatric multisystem inflammatory disease between April and June 2020 were included in this study. MAIN OUTCOME(S) AND MEASURE(S): Dysphonia: GRBAS Perceptual Severity Scores, Vocal Handicap Index scores and the Vocal Tract Discomfort Scale. Dysphagia: Functional Oral Intake Scale.

resultsFifty children met the diagnostic criteria for PIMS-TS. 33 (66%) were male. Median age was 10 years (range: 1-17). 36 (72%) were of Black, Asian or minority ethnic background. Nine (18%) required specialist assessment and management of dysphagia and/or dysphonia. Five (55%) were male with a median age of 9 years 7 months (range: 1-15 years). Symptoms typically resolved within three months. Two children presented with persisting dysphonia three months post-presentation. Neurological, inflammatory, and iatrogenic causes of dysphagia and dysphonia were identified. CONCLUSIONS AND RELEVANCE: Dysphonia and dysphagia are present in children with PIMS-TS. Further data is required to understand pathophysiology, estimate incidence, and determine prognostic factors. This preliminary data highlights the need for dysphagia and dysphonia screening and timely referral for specialist, multidisciplinary assessment and treatment to ensure short-term aspiration risk is managed and long-term, functional outcomes are optimised.

Indexed as

COVID-19Deglutition DisordersDysphoniaChildHumansInfantMaleRetrospective StudiesSARS-CoV-2Systemic Inflammatory Response SyndromeDysphagiaDysphoniaPIMS-TSSARS-CoV-2

Identifiers

PMID34237522
PMCPMC9754852
OpenAlexW3182088279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.